Works matching AU Lötsch, Jörn

Results: 140

Abuse-Deterrent Opioid Formulations: Pharmacokinetic and Pharmacodynamic Considerations.

Published in:

2016

By:

Walter, Carmen;
Knothe, Claudia;
Lötsch, Jörn;
Lötsch, Jörn

Publication type:

journal article

Pharmacogenetics of new analgesics.

Published in:

2011

By:

Lötsch, Jörn;
Geisslinger, Gerd;
Lötsch, Jörn

Publication type:

journal article

Genetic predictors of the clinical response to opioid analgesics: clinical utility and future perspectives.

Published in:

2004

By:

Lötsch, Jörn;
Skarke, Carsten;
xFC;rgen#Liefhold, J&;
Geisslinger, Gerd;
Lötsch, Jörn;
Liefhold, Jürgen

Publication type:

journal article

Non-invasive combined surrogates of remifentanil blood concentrations with relevance to analgesia.

Published in:

Naunyn-Schmiedeberg's Archives of Pharmacology, 2013, v. 386, n. 10, p. 865, doi. 10.1007/s00210-013-0889-5

By:

Lötsch, Jörn;
Skarke, Carsten;
Darimont, Jutta;
Zimmermann, Michael;
Bräutigam, Lutz;
Geisslinger, Gerd;
Ultsch, Alfred;
Oertel, Bruno

Publication type:

Article

Machine learning and biological validation identify sphingolipids as potential mediators of paclitaxel-induced neuropathy in cancer patients.

Published in:

eLife, 2024, p. 1, doi. 10.7554/eLife.91941

By:

Lötsch, Jörn;
Gasimli, Khayal;
Malkusch, Sebastian;
Hahnefeld, Lisa;
Angioni, Carlo;
Schreiber, Yannick;
Trautmann, Sandra;
Wedel, Saskia;
Thomas, Dominique;
Bouzas, Nerea Ferreiros;
Brandts, Christian H.;
Schnappauf, Benjamin;
Solbach, Christine;
Geisslinger, Gerd;
Sisignano, Marco

Publication type:

Article

Machine learning identifies right index finger tenderness as key signal of DAS28-CRP based psoriatic arthritis activity.

Published in:

Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-49574-4

By:

Rischke, Samuel;
Poor, Sorwe Mojtahed;
Gurke, Robert;
Hahnefeld, Lisa;
Köhm, Michaela;
Ultsch, Alfred;
Geisslinger, Gerd;
Behrens, Frank;
Lötsch, Jörn

Publication type:

Article

A perspective of randomness in a clinical test of olfactory performance.

Published in:

Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-45135-x

By:

Lötsch, Jörn;
Hummel, Thomas;
Ultsch, Alfred

Publication type:

Article

Association of genetic and psychological factors with persistent pain after cosmetic thoracic surgery.

Published in:

Journal of Pain Research, 2015, v. 8, p. 829, doi. 10.2147/JPR.S90434

By:

Dimova, Violeta;
Lötsch, Jörn;
Hühne, Kathrin;
Winterpacht, Andreas;
Heesen, Michael;
Parthum, Andreas;
Weber, Peter G.;
Carbon, Roman;
Griessinger, Norbert;
Sittl, Reinhard;
Lautenbacher, Stefan

Publication type:

Article

A data science-based analysis of seasonal patterns in outpatient presentations due to olfactory dysfunction.

Published in:

Rhinology, 2020, v. 58, n. 2, p. 151, doi. 10.4193/Rhin19.099

By:

Lötsch, Jörn;
Hummel, Thomas

Publication type:

Article

A brain-lesion pattern based algorithm for the diagnosis of posttraumatic olfactory loss.

Published in:

Rhinology, 2015, v. 53, n. 4, p. 365, doi. 10.4193/Rhin15.010

By:

Lötsch, Jörn;
Reither, Nicole;
Bogdanov, Vasyl;
Hähner, Antje;
Ultsch, Alfred;
Hill, Konstanze;
Hummel, Thomas

Publication type:

Article

Clinical significance of results from olfactory testing.

Published in:

2006

By:

Gudziol V;
Lötsch J;
Hähner A;
Zahnert T;
Hummel T;
Gudziol, Volker;
Lötsch, Jörn;
Hähner, Antje;
Zahnert, Thomas;
Hummel, Thomas

Publication type:

journal article

Clinical Significance of Results from Olfactory Testing.

Published in:

Laryngoscope, 2006, v. 116, n. 10, p. 1858, doi. 10.1097/01.mlg.0000234915.51189.cb

By:

Gudziol, Volker;
Lötsch, Jörn;
Hähner, Antje;
Zahnert, Thomas;
Hummel, Thomas

Publication type:

Article

Higher pain scores, similar opioid doses and side effects associated with antipyretic analgesics in specialised tertiary pain care.

Published in:

Inflammation Research, 2010, v. 59, n. 11, p. 989, doi. 10.1007/s00011-010-0215-3

By:

Lötsch, Jörn;
Freynhagen, Rainer;
Hentig, Nils;
Griessinger, Norbert;
Zimmermann, Michael;
Sittl, Reinhard;
Geisslinger, Gerd

Publication type:

Article

Revisiting Fold-Change Calculation: Preference for Median or Geometric Mean over Arithmetic Mean-Based Methods.

Published in:

Biomedicines, 2024, v. 12, n. 8, p. 1639, doi. 10.3390/biomedicines12081639

By:

Lötsch, Jörn;
Kringel, Dario;
Ultsch, Alfred

Publication type:

Article

Data-science based analysis of perceptual spaces of odors in olfactory loss.

Published in:

Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-89969-9

By:

Lötsch, Jörn;
Ultsch, Alfred;
Hähner, Antje;
Willgeroth, Vivien;
Bensafi, Moustafa;
Zaliani, Andrea;
Hummel, Thomas

Publication type:

Article

R-flurbiprofen attenuates experimental autoimmune encephalomyelitis in mice.

Published in:

EMBO Molecular Medicine, 2014, v. 6, n. 11, p. 1398, doi. 10.15252/emmm.201404168

By:

Schmitz, Katja;
Bruin, Natasja;
Bishay, Philipp;
Männich, Julia;
Häussler, Annett;
Altmann, Christine;
Ferreirós, Nerea;
Lötsch, Jörn;
Ultsch, Alfred;
Parnham, Michael J;
Geisslinger, Gerd;
Tegeder, Irmgard

Publication type:

Article

Machine-learned analysis of global and glial/opioid intersection–related DNA methylation in patients with persistent pain after breast cancer surgery.

Published in:

Clinical Epigenetics, 2019, v. 11, n. 1, p. N.PAG, doi. 10.1186/s13148-019-0772-4

By:

Kringel, Dario;
Kaunisto, Mari A.;
Kalso, Eija;
Lötsch, Jörn

Publication type:

Article

Extended cortical activations during evaluating successive pain stimuli.

Published in:

Social Cognitive & Affective Neuroscience, 2012, v. 7, n. 6, p. 698

By:

Lötsch, Jörn;
Walter, Carmen;
Felden, Lisa;
Preibisch, Christine;
Nöth, Ulrike;
Martin, Till;
Anti, Sandra;
Deichmann, Ralf;
Oertel, Bruno G.

Publication type:

Article

Integrated Computational Analysis of Genes Associated with Human Hereditary Insensitivity to Pain. A Drug Repurposing Perspective.

Published in:

Frontiers in Molecular Neuroscience, 2017, p. 1, doi. 10.3389/fnmol.2017.00252

By:

Lötsch, Jörn;
Lippmann, Catharina;
Kringel, Dario;
Ultsch, Alfred

Publication type:

Article

What do all the (human) micro-RNAs do?

Published in:

BMC Genomics, 2014, v. 15, n. 1, p. 1, doi. 10.1186/1471-2164-15-976

By:

Ultsch, Alfred;
Lötsch, Jörn

Publication type:

Article

High Glucosylceramides and Low Anandamide Contribute to Sensory Loss and Pain in Parkinson's Disease.

Published in:

Movement Disorders, 2020, v. 35, n. 10, p. 1822, doi. 10.1002/mds.28186

By:

Klatt‐Schreiner, Katharina;
Valek, Lucie;
Kang, Jun‐Suk;
Khlebtovsky, Alexander;
Trautmann, Sandra;
Hahnefeld, Lisa;
Schreiber, Yannick;
Gurke, Robert;
Thomas, Dominique;
Wilken‐Schmitz, Annett;
Wicker, Sabine;
Auburger, Georg;
Geisslinger, Gerd;
Lötsch, Jörn;
Pfeilschifter, Waltraud;
Djaldetti, Ruth;
Tegeder, Irmgard

Publication type:

Article

Self-Ratings of Olfactory Function and Their Relation to Olfactory Test Scores. A Data Science-Based Analysis in Patients with Nasal Polyposis.

Published in:

Applied Sciences (2076-3417), 2021, v. 11, n. 16, p. 7279, doi. 10.3390/app11167279

By:

Lötsch, Jörn;
Hintschich, Constantin A.;
Petridis, Petros;
Pade, Jürgen;
Hummel, Thomas

Publication type:

Article

Development of an AmpliSeqTM Panel for Next-Generation Sequencing of a Set of Genetic Predictors of Persisting Pain.

Published in:

Frontiers in Pharmacology, 2018, p. N.PAG, doi. 10.3389/fphar.2018.01008

By:

Kringel, Dario;
Kaunisto, Mari A.;
Lippmann, Catharina;
Kalso, Eija;
Lötsch, Jörn

Publication type:

Article

Artificial intelligence and machine learning in clinical pharmacological research.

Published in:

Expert Review of Clinical Pharmacology, 2024, v. 17, n. 1, p. 79, doi. 10.1080/17512433.2023.2294005

By:

Mayer, Benjamin;
Kringel, Dario;
Lötsch, Jörn

Publication type:

Article

High-Throughput Analysis of Global DNA Methylation Using Methyl-Sensitive Digestion.

Published in:

PLoS ONE, 2016, v. 11, n. 10, p. 1, doi. 10.1371/journal.pone.0163184

By:

Shiratori, Hiromi;
Feinweber, Carmen;
Knothe, Claudia;
Lötsch, Jörn;
Thomas, Dominique;
Geisslinger, Gerd;
Parnham, Michael J.;
Resch, Eduard

Publication type:

Article

Functional genomics suggest neurogenesis in the adult human olfactory bulb.

Published in:

Brain Structure & Function, 2014, v. 219, n. 6, p. 1991, doi. 10.1007/s00429-013-0618-3

By:

Lötsch, Jörn;
Schaeffeler, Elke;
Mittelbronn, Michel;
Winter, Stefan;
Gudziol, Volker;
Schwarzacher, Stephan;
Hummel, Thomas;
Doehring, Alexandra;
Schwab, Matthias;
Ultsch, Alfred

Publication type:

Article

Computational functional genomics based analysis of pain-relevant micro-RNAs.

Published in:

Human Genetics, 2015, v. 134, n. 11/12, p. 1221, doi. 10.1007/s00439-015-1600-3

By:

Lötsch, Jörn;
Niederberger, Ellen;
Ultsch, Alfred

Publication type:

Article

Machine learning identifies fatigue as a key symptom of fibromyalgia reflected in tyrosine, purine, pyrimidine, and glutaminergic metabolism.

Published in:

CTS: Clinical & Translational Science, 2024, v. 17, n. 3, p. 1, doi. 10.1111/cts.13740

By:

Zetterman, Teemu;
Nieminen, Anni I.;
Markkula, Ritva;
Kalso, Eija;
Lötsch, Jörn

Publication type:

Article

Peripheral opioid analgesia in experimental human pain models.

Published in:

Brain: A Journal of Neurology, 2003, v. 126, n. 5, p. 1092, doi. 10.1093/brain/awg115

By:

Irmgard Tegeder;
Silke Meier;
Maria Burian;
Helmut Schmidt;
Gerd Geisslinger;
Jörn Lötsch

Publication type:

Article

Visual evoked potentials in migraine patients: alterations depend on pattern spatial frequency.

Published in:

Brain: A Journal of Neurology, 1999, v. 122, n. 6, p. 1147, doi. 10.1093/brain/122.6.1147

By:

Oelkers, Rieke;
Grosser, Konrad;
Lang, Eberhard;
Geisslinger, Gerd;
Kobal, Gerd;
Brune, Kay;
Lötsch, Jörn

Publication type:

Article

The cyclooxygenase 2 genetic variant −765G>C does not modulate the effects of celecoxib on prostaglandin E2 production*.

Published in:

Clinical Pharmacology & Therapeutics, 2006, v. 80, n. 6, p. 621, doi. 10.1016/j.clpt.2006.08.021

By:

Skarke, Carsten;
Reus, Maximilian;
Schmidt, Ronald;
Grundei, Inga;
Schuss, Patrick;
Geisslinger, Gerd;
Lötsch, Jörn

Publication type:

Article

Misestimating the role of an active metabolite when modeling the effects after administration of the parent compound only.

Published in:

2006

By:

Lötsch, Jörn;
Geisslinger, Gerd

Publication type:

Letter

Evidence for morphine-independent central nervous opioid effects after administration of codeine: Contribution of other codeine metabolites*.

Published in:

Clinical Pharmacology & Therapeutics, 2006, v. 79, n. 1, p. 35, doi. 10.1016/j.clpt.2005.09.005

By:

Lötsch, Jörn;
Skarke, Carsten;
Schmidt, Helmut;
Rohrbacher, Maren;
Hofmann, Ute;
Schwab, Matthias;
Geisslinger, Gerd

Publication type:

Article

Modulation of the central nervous effects of levomethadone by genetic polymorphisms potentially affecting its metabolism, distribution, and drug action.

Published in:

Clinical Pharmacology & Therapeutics, 2006, v. 79, n. 1, p. 72, doi. 10.1016/j.clpt.2005.09.010

By:

Lötsch, Jörn;
Skarke, Carsten;
Wieting, Johannes;
Oertel, Bruno Georg;
Schmidt, Helmut;
Brockmöller, Jürgen;
Geisslinger, Gerd

Publication type:

Article

The 5-hydroxytryptamine 4 receptor agonist mosapride does not antagonize morphine-induced respiratory depression

Published in:

Clinical Pharmacology & Therapeutics, 2005, v. 78, n. 3, p. 278, doi. 10.1016/j.clpt.2005.05.010

By:

Lötsch, Jörn;
Skarke, Carsten;
Schneider, Andreas;
Hummel, Thomas;
Geisslinger, Gerd

Publication type:

Article

Respiratory and miotic effects of morphine in healthy volunteers when P-glycoprotein is blocked by quinidine*.

Published in:

Clinical Pharmacology & Therapeutics, 2003, v. 74, n. 4, p. 303, doi. 10.1016/S0009-9236(03)00220-0

By:

Skarke, Carsten;
Jarrar, Marwan;
Erb, Katharina;
Schmidt, Helmut;
Geisslinger, Gerd;
Lötsch, Jörn

Publication type:

Article

Analgesic effects of morphine and morphine-6-glucuronide in a transcutaneous electrical pain model in healthy volunteers*.

Published in:

Clinical Pharmacology & Therapeutics, 2003, v. 73, n. 1, p. 107, doi. 10.1067/mcp.2003.5

By:

Skarke, Carsten;
Darimont, Jutta;
Schmidt, Helmut;
Geisslinger, Gerd;
Lötsch, Jörn

Publication type:

Article

Pharmacokinetic modeling to predict morphine and morphine-6-glucuronide plasma concentrations in healthy young volunteers*.

Published in:

Clinical Pharmacology & Therapeutics, 2002, v. 72, n. 2, p. 151, doi. 10.1067/mcp.2002.126172

By:

Lötsch, Jörn;
Skarke, Carsten;
Schmidt, Helmut;
Liefhold, Jürgen;
Geisslinger, Gerd

Publication type:

Article

Tissue distribution of imipenem in critically ill patients*.

Published in:

Clinical Pharmacology & Therapeutics, 2002, v. 71, n. 5, p. 325, doi. 10.1067/mcp.2002.122526

By:

Tegeder, Irmgard;
Schmidtko, Achim;
Bräutigam, Lutz;
Kirschbaum, Andreas;
Geisslinger, Gerd;
Lötsch, Jörn

Publication type:

Article

Comparison of inhibitory effects of meloxicam and diclofenac on human thromboxane biosynthesis after single doses and at steady state*.

Published in:

Clinical Pharmacology & Therapeutics, 1999, v. 65, n. 5, p. 533, doi. 10.1016/S0009-9236(99)70073-1

By:

Tegeder, Irmgard;
Lötsch, Jörn;
Krebs, Sabine;
Muth-Selbach, Uta;
Brune, Kay;
Geisslinger, Gerd

Publication type:

Article

Application of microdialysis for the determination of muscle and subcutaneous tissue concentrations after oral and topical ibuprofen administration*.

Published in:

Clinical Pharmacology & Therapeutics, 1999, v. 65, n. 4, p. 357, doi. 10.1016/S0009-9236(99)70128-1

By:

Tegeder, Irmgard;
Muth-Selbach, Uta;
Lötsch, Jörn;
Rüsing, Guido;
Oelkers, Rieke;
Brune, Kay;
Meller, Steve;
Kelm, Garry R.;
Sörgel, Fritz;
Geisslinger, Gerd

Publication type:

Article

Pharmacokinetics of meropenem in critically ill patients with acute renal failure undergoing continuous venovenous hemofiltration*.

Published in:

Clinical Pharmacology & Therapeutics, 1999, v. 65, n. 1, p. 50, doi. 10.1016/S0009-9236(99)70121-9

By:

Tegeder, Irmgard;
Neumann, Frank;
Bremer, Frank;
Brune, Kay;
Lötsch, Jörn;
Geisslinger, Gerd

Publication type:

Article

Pharmacokinetics of morphine-6-glucuronide and its formation from morphine after intravenous administration*.

Published in:

Clinical Pharmacology & Therapeutics, 1998, v. 63, n. 6, p. 629, doi. 10.1016/S0009-9236(98)90086-8

By:

Lötsch, Jörn;
Weiss, Michael;
Kobal, Gerd;
Geisslinger, Gerd

Publication type:

Article

Pharmacokinetics of morphine and its glucuronides after intravenous infusion of morphine and morphine-6-glucuronide in healthy volunteers*.

Published in:

Clinical Pharmacology & Therapeutics, 1996, v. 60, n. 3, p. 316, doi. 10.1016/S0009-9236(96)90058-2

By:

Lötsch, Jörn;
Stockmann, Anne;
Kobal, Gerd;
Brune, Kay;
Waibel, Rainer;
Schmidt, Norbert;
Geisslinger, Gerd

Publication type:

Article

Machine-learning-derived rules set excludes risk of Parkinson's disease in patients with olfactory or gustatory symptoms with high accuracy.

Published in:

Journal of Neurology, 2020, v. 267, n. 2, p. 469, doi. 10.1007/s00415-019-09604-6

By:

Lötsch, Jörn;
Haehner, Antje;
Hummel, Thomas

Publication type:

Article

A short olfactory test based on the identification of three odors.

Published in:

Journal of Neurology, 2010, v. 257, n. 8, p. 1316, doi. 10.1007/s00415-010-5516-5

By:

Hummel, Thomas;
Pfetzing, Ute;
Lötsch, Jörn

Publication type:

Article

Pitfalls of Using Multinomial Regression Analysis to Identify Class-Structure-Relevant Variables in Biomedical Data Sets: Why a Mixture of Experts (MOE) Approach Is Better.

Published in:

BioMedInformatics, 2023, v. 3, n. 4, p. 869, doi. 10.3390/biomedinformatics3040054

By:

Lötsch, Jörn;
Ultsch, Alfred

Publication type:

Article

Enhancing Explainable Machine Learning by Reconsidering Initially Unselected Items in Feature Selection for Classification.

Published in:

BioMedInformatics, 2022, v. 2, n. 4, p. 701, doi. 10.3390/biomedinformatics2040047

By:

Lötsch, Jörn;
Ultsch, Alfred

Publication type:

Article

A Biomedical Case Study Showing That Tuning Random Forests Can Fundamentally Change the Interpretation of Supervised Data Structure Exploration Aimed at Knowledge Discovery.

Published in:

BioMedInformatics, 2022, v. 2, n. 4, p. 544, doi. 10.3390/biomedinformatics2040034

By:

Lötsch, Jörn;
Mayer, Benjamin

Publication type:

Article

Distribution Optimization: An evolutionary algorithm to separate Gaussian mixtures.

Published in:

Scientific Reports, 2020, v. 10, n. 1, p. 1, doi. 10.1038/s41598-020-57432-w

By:

Lerch, Florian;
Ultsch, Alfred;
Lötsch, Jörn

Publication type:

Article