Works matching DE "TDP-43 proteinopathies"

Results: 140

Proteomics Analysis of the TDP‐43 Interactome in Cellular Models of ALS Pathogenesis.

Published in:

Journal of Neurochemistry, 2025, v. 169, n. 5, p. 1, doi. 10.1111/jnc.70079

By:

Cheng, Flora;
Chapman, Tyler;
Venturato, Juliana;
Davidson, Jennilee M.;
Polido, Stella A.;
Rosa‐Fernandes, Livia;
San Gil, Rebecca;
Suddull, Hannah J.;
Zhang, Selina;
Macaslam, Chiara Y.;
Szwaja, Paulina;
Chung, Roger;
Walker, Adam K.;
Rayner, Stephanie L.;
Morsch, Marco;
Lee, Albert

Publication type:

Article

Pathobiological Subtypes of Alzheimer Disease.

Published in:

Dementia & Geriatric Cognitive Disorders, 2020, v. 49, n. 4, p. 321, doi. 10.1159/000508625

By:

Jellinger, Kurt A.

Publication type:

Article

Theme 10 Therapeutic strategies.

Published in:: 2017
Publication type:: Abstract

Theme 6 Biomarkers.

Published in:: 2017
Publication type:: Abstract

Sessions 1 - 11.

Published in:: 2017
Publication type:: Proceeding

In this issue.

Published in:: Neuropathology & Applied Neurobiology, 2015, v. 41, n. 5, p. 575, doi. 10.1111/nan.12255
Publication type:: Article

Laminar distribution of the pathological changes in sporadic frontotemporal lobar degeneration with transactive response (TAR) DNA-binding protein of 43 kDa (TDP-43) proteinopathy: a quantitative study using polynomial curve fitting.

Published in:

Neuropathology & Applied Neurobiology, 2013, v. 39, n. 4, p. 335, doi. 10.1111/j.1365-2990.2012.01291.x

By:

Armstrong, R. A.;
Hamilton, R. L.;
Mackenzie, I. R. A.;
Hedreen, J.;
Cairns, N. J.

Publication type:

Article

Postbiotics as Molecules Targeting Cellular Events of Aging Brain—The Role in Pathogenesis, Prophylaxis and Treatment of Neurodegenerative Diseases.

Published in:

Nutrients, 2024, v. 16, n. 14, p. 2244, doi. 10.3390/nu16142244

By:

Głowacka, Pola;
Oszajca, Katarzyna;
Pudlarz, Agnieszka;
Szemraj, Janusz;
Witusik-Perkowska, Monika

Publication type:

Article

Quantitative analysis of cryptic splicing associated with TDP-43 depletion.

Published in:

BMC Medical Genomics, 2017, v. 10, p. 1, doi. 10.1186/s12920-017-0274-1

By:

Humphrey, Jack;
Emmett, Warren;
Fratta, Pietro;
Isaacs, Adrian M.;
Plagnol, Vincent

Publication type:

Article

TDP-43 and NEAT long non-coding RNA: Roles in neurodegenerative disease.

Published in:

Frontiers in Cellular Neuroscience, 2022, v. 16, p. 1, doi. 10.3389/fncel.2022.954912

By:

Sekar, Durairaj;
Tusubira, Deusdedit;
Ross, Kehinde

Publication type:

Article

TDP-43 as a potential retinal biomarker for neurodegenerative diseases.

Published in:

Frontiers in Neuroscience, 2025, p. 1, doi. 10.3389/fnins.2025.1533045

By:

Glashutter, Margit;
Wijesinghe, Printha;
Matsubara, Joanne A.

Publication type:

Article

Neuropathological assessments of the pathology in frontotemporal lobar degeneration with TDP43-positive inclusions: an inter-laboratory study by the BrainNet Europe consortium.

Published in:

Journal of Neural Transmission, 2015, v. 122, n. 7, p. 957, doi. 10.1007/s00702-014-1304-1

By:

Alafuzoff, Irina;
Pikkarainen, Maria;
Neumann, Manuela;
Arzberger, Thomas;
Al-Sarraj, Safa;
Bodi, Istvan;
Bogdanovic, Nenad;
Bugiani, Orso;
Ferrer, Isidro;
Gelpi, Ellen;
Gentleman, Stephen;
Giaccone, Giorgio;
Graeber, Manuel;
Hortobagyi, Tibor;
Ince, Paul;
Ironside, James;
Kavantzas, Nikolaos;
King, Andrew;
Korkolopoulou, Penelope;
Kovács, Gábor

Publication type:

Article

Erratum to: Neuropathological assessments of the pathology in frontotemporal lobar degeneration with TDP43-positive inclusions: an inter-laboratory study by the BrainNet Europe consortium.

Published in:

2015

By:

Alafuzoff, Irina;
Pikkarainen, Maria;
Neumann, Manuela;
Arzberger, Thomas;
Al-Sarraj, Safa;
Bodi, Istvan;
Bogdanovic, Nenad;
Bugiani, Orso;
Ferrer, Isidro;
Gelpi, Ellen;
Gentleman, Stephen;
Giaccone, Giorgio;
Graeber, Manuel;
Hortobagyi, Tibor;
Ince, Paul;
Ironside, James;
Kavantzas, Nikolaos;
King, Andrew;
Korkolopoulou, Penelope;
Kovács, Gábor

Publication type:

Erratum

Synaptic Paths to Neurodegeneration: The Emerging Role of TDP-43 and FUS in Synaptic Functions.

Published in:

Neural Plasticity, 2018, p. 1, doi. 10.1155/2018/8413496

By:

Ling, Shuo-Chien

Publication type:

Article

A tribute to John Q. Trojanowski (1946–2022), neuropathologist extraordinaire.

Published in:

Brain Pathology, 2022, v. 32, n. 3, p. 1, doi. 10.1111/bpa.13066

By:

Goedert, Michel;
Spillantini, Maria Grazia

Publication type:

Article

Detection and quantification of novel C‐terminal TDP‐43 fragments in ALS‐TDP.

Published in:

Brain Pathology, 2021, v. 31, n. 4, p. 1, doi. 10.1111/bpa.12923

By:

Feneberg, Emily;
Charles, Philip D.;
Finelli, Mattéa J.;
Scott, Connor;
Kessler, Benedikt M.;
Fischer, Roman;
Ansorge, Olaf;
Gray, Elizabeth;
Talbot, Kevin;
Turner, Martin R.

Publication type:

Article

Hippocampal sclerosis, hippocampal neuron loss patterns and TDP‐43 in the aged population.

Published in:

Brain Pathology, 2018, v. 28, n. 4, p. 548, doi. 10.1111/bpa.12556

By:

Hokkanen, Suvi R. K.;
Hunter, Sally;
Polvikoski, Tuomo M.;
Keage, Hannah A. D.;
Minett, Thais;
Matthews, Fiona E.;
Brayne, Carol;
MRC CFAS and CC75C Study Group

Publication type:

Article

TDP-43 pathology in Alzheimer's disease, dementia with Lewy bodies and ageing.

Published in:

Brain Pathology, 2017, v. 27, n. 4, p. 472, doi. 10.1111/bpa.12424

By:

McAleese, Kirsty E.;
Walker, Lauren;
Erskine, Daniel;
Thomas, Alan J.;
McKeith, Ian G.;
Attems, Johannes

Publication type:

Article

Multiproteinopathy, neurodegeneration and old age: a case study.

Published in:

2018

By:

Rojas, Julio C.;
Stephens, Melanie L.;
Rabinovici, Gil D.;
Kramer, Joel H.;
Miller, Bruce L.;
Seeley, William W.

Publication type:

journal article

Decreased Hsp90 activity protects against TDP-43 neurotoxicity in a C. elegans model of amyotrophic lateral sclerosis.

Published in:

PLoS Genetics, 2024, v. 20, n. 12, p. 1, doi. 10.1371/journal.pgen.1011518

By:

Garcia-Toscano, Laura;
Currey, Heather N.;
Hincks, Joshua C.;
Stair, Jade G.;
Lehrbach, Nicolas J.;
Liachko, Nicole F.

Publication type:

Article

Clinical Update.

Published in:

Nursing & Residential Care, 2019, v. 21, n. 7, p. 367, doi. 10.12968/nrec.2019.21.7.367

By:

Nazarko, Linda

Publication type:

Article

Regulation of TDP-43 phosphorylation in aging and disease.

Published in:

GeroScience, 2021, v. 43, n. 4, p. 1605, doi. 10.1007/s11357-021-00383-5

By:

Eck, Randall J.;
Kraemer, Brian C.;
Liachko, Nicole F.

Publication type:

Article

Co-deposition of SOD1, TDP-43 and p62 proteinopathies in ALS: evidence for multifaceted pathways underlying neurodegeneration.

Published in:

Acta Neuropathologica Communications, 2022, v. 10, n. 1, p. 1, doi. 10.1186/s40478-022-01421-9

By:

Trist, Benjamin G.;
Fifita, Jennifer A.;
Hogan, Alison;
Grima, Natalie;
Smith, Bradley;
Troakes, Claire;
Vance, Caroline;
Shaw, Christopher;
Al-Sarraj, Safa;
Blair, Ian P.;
Double, Kay L.

Publication type:

Article

Intracellular dynamics of Ataxin-2 in the human brains with normal and frontotemporal lobar degeneration with TDP-43 inclusions.

Published in:

Acta Neuropathologica Communications, 2020, v. 8, n. 1, p. N.PAG, doi. 10.1186/s40478-020-01055-9

By:

Watanabe, Ryohei;
Higashi, Shinji;
Nonaka, Takashi;
Kawakami, Ito;
Oshima, Kenichi;
Niizato, Kazuhiro;
Akiyama, Haruhiko;
Yoshida, Mari;
Hasegawa, Masato;
Arai, Tetsuaki

Publication type:

Article

Prion-like Spreading of Disease in TDP-43 Proteinopathies.

Published in:

Brain Sciences (2076-3425), 2024, v. 14, n. 11, p. 1132, doi. 10.3390/brainsci14111132

By:

Pongrácová, Emma;
Buratti, Emanuele;
Romano, Maurizio

Publication type:

Article

Intramuscular Nerve Bundles Reflect TDP‐43 Pathology in the Medulla and Spinal Cord of ALS Patients.

Published in:

Neuropathology & Applied Neurobiology, 2025, v. 51, n. 2, p. 1, doi. 10.1111/nan.70016

By:

Kurashige, Takashi;
Murao, Tomomi;
Kanaya, Yuhei;
Dodo, Yoriko;
Sugiura, Tomohito;
Kuraoka, Kazuya;
Ohshita, Tomohiko

Publication type:

Article

Targeting shared pathways in tauopathies and age-related macular degeneration: implications for novel therapies.

Published in:

Frontiers in Aging Neuroscience, 2024, p. 1, doi. 10.3389/fnagi.2024.1371745

By:

Rinaldi, Michele;
Pezone, Antonio;
Quadrini, Gaia Italia;
Abbadessa, Gianmarco;
Laezza, Maria Paola;
Passaro, Maria Laura;
Porcellini, Antonio;
Costagliola, Ciro

Publication type:

Article

An in situ and in vitro investigation of cytoplasmic TDP-43 inclusions reveals the absence of a clear amyloid signature.

Published in:

Annals of Medicine, 2023, v. 55, n. 1, p. 72, doi. 10.1080/07853890.2022.2148734

By:

Cascella, Roberta;
Banchelli, Martina;
Abolghasem Ghadami, Seyyed;
Ami, Diletta;
Gagliani, Maria Cristina;
Bigi, Alessandra;
Staderini, Tommaso;
Tampellini, Davide;
Cortese, Katia;
Cecchi, Cristina;
Natalello, Antonino;
Adibi, Hadi;
Matteini, Paolo;
Chiti, Fabrizio

Publication type:

Article

Identification of genes associated with dissociation of cognitive performance and neuropathological burden: Multistep analysis of genetic, epigenetic, and transcriptional data.

Published in:

2017

By:

White, Charles C.;
Yang, Hyun-Sik;
Yu, Lei;
Chibnik, Lori B.;
Dawe, Robert J.;
Yang, Jingyun;
Klein, Hans-Ulrich;
Felsky, Daniel;
Ramos-Miguel, Alfredo;
Arfanakis, Konstantinos;
Honer, William G.;
Sperling, Reisa A.;
Schneider, Julie A.;
Bennett, David A.;
De Jager, Philip L.

Publication type:

journal article

Heterogeneous nuclear ribonucleoprotein D — an understudied subfamily affected in sporadic TDP-43 proteinopathies.

Published in:

Brain Communications, 2024, v. 6, n. 6, p. 1, doi. 10.1093/braincomms/fcae352

By:

Pinkerton, Monica;
Adler, Gabrielle L;
Ledger, Mallory;
Ni, Chen Yue;
Yang, Yue;
Tan, Rachel H

Publication type:

Article

TDP-43 overexpression in the hypothalamus drives neuropathology, dysregulates metabolism and impairs behavior in mice.

Published in:

Acta Neuropathologica Communications, 2025, v. 13, n. 1, p. 1, doi. 10.1186/s40478-025-02018-8

By:

Bergh, Sofia;
Casadei, Nicolas;
Gabery, Sanaz;
Simonsson, Oskar;
Duarte, João M. N.;
Kirik, Deniz;
Nguyen, Huu Phuc;
Petersén, Åsa

Publication type:

Article

An autopsy case of type A FTLD‐TDP with a GRN mutation presenting with the logopenic variant of primary progressive aphasia at onset and with corticobasal syndrome subsequently.

Published in:

Neuropathology, 2025, v. 45, n. 1, p. 38, doi. 10.1111/neup.12980

By:

Tomenaga, Takafumi;
Minatani, Shinobu;
Namba, Hiroto;
Takeda, Akitoshi;
Yoshizaki, Takahito;
Kawabe, Joji;
Keyoumu, Nazere;
Morino, Hiroyuki;
Higuchi, Makoto;
Matsubara, Tomoyasu;
Hatsuta, Hiroyuki;
Hasegawa, Masato;
Murayama, Shigeo;
Itoh, Yoshiaki

Publication type:

Article

Retrospective neuropathological diagnosis of TDP‐43 proteinopathies: Factors affecting immunoreactivity of phosphorylated TDP‐43 in fixed post‐mortem brain tissue.

Published in:

Neuropathology, 2024, v. 44, n. 2, p. 173, doi. 10.1111/neup.12937

By:

Robinson, Andrew C.;
Davidson, Yvonne S.;
Minshull, James;
Lally, Imogen;
Walker, Liam;
Mann, David M.A.;
Roncaroli, Federico

Publication type:

Article

Significance and limitation of the pathological classification of TDP-43 proteinopathy.

Published in:

Neuropathology, 2014, v. 34, n. 6, p. 578, doi. 10.1111/neup.12138

By:

Arai, Tetsuaki

Publication type:

Article

Cortical degeneration in frontotemporal lobar degeneration with TDP-43 proteinopathy caused by progranulin gene mutation.

Published in:

International Journal of Neuroscience, 2014, v. 124, n. 12, p. 894, doi. 10.3109/00207454.2014.890620

By:

Armstrong, Richard A.

Publication type:

Article

Dysregulation of Translation in TDP-43 Proteinopathies: Deficits in the RNA Supply Chain and Local Protein Production.

Published in:

Frontiers in Neuroscience, 2022, v. 16, p. 1, doi. 10.3389/fnins.2022.840357

By:

Bjork, Reed T.;
Mortimore, Nicholas P.;
Loganathan, Suvithanandhini;
Zarnescu, Daniela C.

Publication type:

Article

Mitigation of TDP-43 toxic phenotype by an RGNEF fragment in amyotrophic lateral sclerosis models.

Published in:

Brain: A Journal of Neurology, 2024, v. 147, n. 6, p. 2053, doi. 10.1093/brain/awae078

By:

Droppelmann, Cristian A;
Campos-Melo, Danae;
Noches, Veronica;
McLellan, Crystal;
Szabla, Robert;
Lyons, Taylor A;
Amzil, Hind;
Withers, Benjamin;
Kaplanis, Brianna;
Sonkar, Kirti S;
Simon, Anne;
Buratti, Emanuele;
Junop, Murray;
Kramer, Jamie M;
Strong, Michael J

Publication type:

Article

The MLO-down on TDP-43.

Published in:

Brain: A Journal of Neurology, 2023, v. 146, n. 9, p. 3565, doi. 10.1093/brain/awad268

By:

Dykstra, Megan;
Barmada, Sami J

Publication type:

Article

Transactive response DNA-binding protein 43 is enriched at the centrosome in human cells.

Published in:

Brain: A Journal of Neurology, 2023, v. 146, n. 9, p. 3624, doi. 10.1093/brain/awad228

By:

Bodin, Alexia;
Greibill, Logan;
Gouju, Julien;
Letournel, Franck;
Pozzi, Silvia;
Julien, Jean-Pierre;
Renaud, Laurence;
Bohl, Delphine;
Millecamps, Stéphanie;
Verny, Christophe;
Cassereau, Julien;
Lenaers, Guy;
Chevrollier, Arnaud;
Tassin, Anne-Marie;
Codron, Philippe

Publication type:

Article

Precision diagnosis and staging of TDP-43 proteinopathies: harnessing the power of artificial intelligence.

Published in:

Brain: A Journal of Neurology, 2023, v. 146, n. 7, p. 2666, doi. 10.1093/brain/awad175

By:

Hickman, Richard A;
Scholz, Sonja W

Publication type:

Article

Data-driven neuropathological staging and subtyping of TDP-43 proteinopathies.

Published in:

Brain: A Journal of Neurology, 2023, v. 146, n. 7, p. 2975, doi. 10.1093/brain/awad145

By:

Young, Alexandra L;
Vogel, Jacob W;
Robinson, John L;
McMillan, Corey T;
Ossenkoppele, Rik;
Wolk, David A;
Irwin, David J;
Elman, Lauren;
Grossman, Murray;
Lee, Virginia M Y;
Lee, Edward B;
Hansson, Oskar

Publication type:

Article

Somatic TARDBP variants as a cause of semantic dementia.

Published in:

2020

By:

Rooij, Jeroen van;
Mol, Merel O;
Melhem, Shamiram;
van der Wal, Pelle;
Arp, Pascal;
Paron, Francesca;
Kaat, Laura Donker;
Seelaar, Harro;
Bank, Netherlands Brain;
Miedema, Suzanne S M;
Oshima, Takuya;
Eggen, Bart J L;
Uitterlinden, André;
Meurs, Joyce van;
Kesteren, Ronald E van;
Smit, August B;
Buratti, Emanuele;
Swieten, John C van;
van Rooij, Jeroen;
Donker Kaat, Laura

Publication type:

journal article

Neuropsychiatric symptoms in limbic-predominant age-related TDP-43 encephalopathy and Alzheimer's disease.

Published in:

2020

By:

Liu, Kathy Y;
Reeves, Suzanne;
McAleese, Kirsty E;
Attems, Johannes;
Francis, Paul;
Thomas, Alan;
Howard, Robert

Publication type:

journal article

Aberrant interaction between FUS and SFPQ in neurons in a wide range of FTLD spectrum diseases.

Published in:

2020

By:

Ishigaki, Shinsuke;
Riku, Yuichi;
Fujioka, Yusuke;
Endo, Kuniyuki;
Iwade, Nobuyuki;
Kawai, Kaori;
Ishibashi, Minaka;
Yokoi, Satoshi;
Katsuno, Masahisa;
Watanabe, Hirohisa;
Mori, Keiko;
Akagi, Akio;
Yokota, Osamu;
Terada, Seishi;
Kawakami, Ito;
Suzuki, Naoki;
Warita, Hitoshi;
Aoki, Masashi;
Yoshida, Mari;
Sobue, Gen

Publication type:

journal article

Selected cryptic exons accumulate in hippocampal cell nuclei in Alzheimer's disease with and without associated TDP-43 proteinopathy.

Published in:

2020

By:

Torres, Pascual;
Andrés-Benito, Pol;
Fernàndez-Bernal, Anna;
Ricart, Marta;
Ayala, Victòria;
Pamplona, Reinald;
Ferrer, Isidro;
Portero-Otin, Manuel

Publication type:

Letter

Reply: Selected cryptic exons accumulate in hippocampal cell nuclei in Alzheimer's disease with and without associated TDP-43 proteinopathy.

Published in:

2020

By:

Nelson, Peter T

Publication type:

Letter

Reply: Limbic-predominant age-related TDP-43 encephalopathy (LATE).

Published in:

2019

By:

Schneider, Julie A;
Nelson, Peter T

Publication type:

Letter

Limbic-predominant age-related TDP-43 encephalopathy (LATE).

Published in:

2019

By:

Larner, Andrew J;
Griffiths, Timothy D

Publication type:

Letter

Neurodegenerative disease concomitant proteinopathies are prevalent, age-related and APOE4-associated.

Published in:

2018

By:

Robinson, John L.;
Lee, Edward B.;
Xie, Sharon X.;
Rennert, Lior;
Suh, EunRan;
Bredenberg, Colin;
Caswell, Carrie;
Van Deerlin, Vivianna M.;
Ning Yan;
Yousef, Ahmed;
Hurtig, Howard I.;
Siderowf, Andrew;
Grossman, Murray;
McMillan, Corey T.;
Miller, Bruce;
Duda, John E.;
Irwin, David J.;
Wolk, David;
Elman, Lauren;
McCluskey, Leo

Publication type:

journal article

The snowball effect of RNA binding protein dysfunction in amyotrophic lateral sclerosis.

Published in:

2018

By:

Fratta, Pietro;
Isaacs, Adrian M.

Publication type:

journal article