We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
HAPLOWSER: a whole-genome haplotype browser for personal genome and metagenome.
- Authors
Jong Hyun Kim; Woo-Cheol Kim; Waterman, Michael S.; Li, Lei M.; Park, Sanghyun
- Abstract
Summary: Haplotype assembly is becoming a very important tool in genome sequencing of human and other organisms. Although haplotypes were previously inferred from genome assemblies, there has never been a comparative haplotype browser that depicts a global picture of whole-genome alignments among haplotypes of different organisms. We introduce a whole-genome HAPLotype brOWSER (HAPLOWSER), providing evolutionary perspectives from multiple aligned haplotypes and functional annotations. Haplowser enables the comparison of haplotypes from metagenomes, and associates conserved regions or the bases at the conserved regions with functional annotations and custom tracks. The associations are quantified for further analysis and presented as pie charts. Functional annotations and custom tracks that are projected onto haplotypes are saved as multiple files in FASTA format. Haplowser provides a user-friendly interface, and can display alignments of haplotypes with functional annotations at any resolution.
- Subjects
GENOMES; GENETICS; GENOMICS; COMPUTER software; HAPLOIDY
- Publication
Bioinformatics, 2009, Vol 25, Issue 18, p2430
- ISSN
1367-4803
- Publication type
Academic Journal
- DOI
10.1093/bioinformatics/btp399