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- Title
Histone acetylation in gene regulation.
- Authors
Verdone, Lorenada; Agricola, Eleonora; Caserta, Micaela; Di Mauro, Ernesto
- Abstract
Genetic information is packaged in the highly dynamic nucleoprotein structure called chromatin. Many biological processes are regulated via post-translational modifications of key proteins. Acetylation of lysine residues at the N-terminal histone tails is one of the most studied covalent modifications influencing gene regulation in eukaryotic cells. This review focuses on the role of enzymes involved in controlling both histone and non-histone proteins acetylation levels in the cell, with particular emphasis on their effects on cancer.
- Subjects
HISTONES; ACETYLATION; GENETIC regulation; GENE expression; CANCER
- Publication
Briefings in Functional Genomics & Proteomics, 2006, Vol 5, Issue 3, p209
- ISSN
1473-9550
- Publication type
Academic Journal
- DOI
10.1093/bfgp/ell028