Title: Histone variant--the structure behind the function.
Authors: Ausió, Juan
Abstract: In recent years, the chromatin field has witnessed a renewed interest in histone variants as pertaining to their structural role, but mainly because of the functional specificity they impart to chromatin. In this review, I am going to discuss several of the most recent structural studies on core histone (H2A.Bbd, H2A.Z, H2A.X, macroH2A, H3.3, CENP-A) and linker histone variants (histone HI microheterogeneity) focusing on their role in nucleosome stability and chromatin fibre dynamics with special emphasis on their possible functional implications. The data accumulated to date indicates that histone variability plays an important role in the histone-mediated regulation of chromatin metabolism. Understanding and deciphering the underlying structural amino acid code behind such variability remains one of the most exciting future challenges in chromatin research.
Subjects: HISTONES; CHROMATIN; GENOMICS; PROTEOMICS; NUCLEOPROTEINS
Publication: Briefings in Functional Genomics & Proteomics, 2006, Vol 5, Issue 3, p228
ISSN: 1473-9550
Publication type: Academic Journal
DOI: 10.1093/bfgp/ell020

Histone variant--the structure behind the function.

Ausió, Juan