Results
Title

DNA methylation, nucleosome formation and positioning.

Authors

Pennings, Sari; Allan, James; Davey, Colin S.

Abstract

Recent mapping of nucleosome positioning on several long gene regions subject to DNA methylation has identified instances of nucleosome repositioning by this base modification. The evidence for an effect of CpG methylation on nucleosome formation and positioning in chromatin is reviewed here in the context of the complex sequence-structure requirements of DNA wrapping around the histone octamer and the role of this epigenetic mark in gene repression.

Subjects

GENES; DNA; METHYLATION; CHROMATIN; HISTONES

Publication

Briefings in Functional Genomics & Proteomics, 2005, Vol 3, Issue 4, p351

ISSN

1473-9550

Publication type

Academic Journal

DOI

10.1093/bfgp/3.4.351