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- Title
DNA methylation, nucleosome formation and positioning.
- Authors
Pennings, Sari; Allan, James; Davey, Colin S.
- Abstract
Recent mapping of nucleosome positioning on several long gene regions subject to DNA methylation has identified instances of nucleosome repositioning by this base modification. The evidence for an effect of CpG methylation on nucleosome formation and positioning in chromatin is reviewed here in the context of the complex sequence-structure requirements of DNA wrapping around the histone octamer and the role of this epigenetic mark in gene repression.
- Subjects
GENES; DNA; METHYLATION; CHROMATIN; HISTONES
- Publication
Briefings in Functional Genomics & Proteomics, 2005, Vol 3, Issue 4, p351
- ISSN
1473-9550
- Publication type
Academic Journal
- DOI
10.1093/bfgp/3.4.351