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Title

Synergistic effect of cerium chloride and calcium chloride alters calcium signaling in keratinocytes to promote epidermal differentiation.

Authors

Tsukui, Kei; Suzuki, Masamitsu; Amma, Miyu; Tokudome, Yoshihiro

Abstract

Epidermal keratinocytes undergo morphological and functional changes during differentiation, eventually being enucleated to become corneocytes. Calcium has been shown to be involved in various cellular functions of epidermal cells, including proliferation, differentiation, and apoptosis. Cerium is a lanthanide-series element and rare earth metal. For skin, cerium oxide has been investigated for use in absorbing UV and promoting wound healing. However, the functions and physiological effects of inorganic cerium on the skin have rarely been investigated. Here, we focused on cerium's function in epidermal keratinocytes and its interaction with calcium by investigating their effects on cell differentiation and intracellular calcium concentration. This study showed that applying cerium chloride to epidermal keratinocytes altered calcium signaling. It also suggested that cerium and calcium induced an increase in intracellular calcium concentration and promoted keratinocyte differentiation.

Subjects

RARE earth metals; KERATINOCYTE differentiation; INTRACELLULAR calcium; CELL physiology; CERIUM

Publication

Bioscience, Biotechnology & Biochemistry, 2024, Vol 88, Issue 12, p1432

ISSN

0916-8451

Publication type

Academic Journal

DOI

10.1093/bbb/zbae131

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