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- Title
Production of a new triterpenoid disaccharide saponin from sequential glycosylation of ganoderic acid A by 2 Bacillus glycosyltransferases.
- Authors
Chang, Te-Sheng; Chiang, Chien-Min; Wu, Jiumn-Yih; Tsai, Yu-Li; Ting, Huei-Ju
- Abstract
Ganoderic acid A (GAA) is a lanostane-type triterpenoid, isolated from medicinal fungus Ganoderma lucidum , and possesses multiple bioactivities. In the present study, GAA was sequentially biotransformed by 2 recently discovered Bacillus glycosyltransferases (GT), BtGT_16345 and BsGT110, and the final product was purified and identified as a new compound, GAA-15,26- O -β-diglucoside, which showed 1024-fold aqueous solubility than GAA.
- Subjects
SAPONINS; GLYCOSYLTRANSFERASES; BACILLUS (Bacteria); DISACCHARIDES; TRITERPENOIDS; GANODERMA lucidum; GLYCOSYLATION
- Publication
Bioscience, Biotechnology & Biochemistry, 2021, Vol 85, Issue 3, p687
- ISSN
0916-8451
- Publication type
Academic Journal
- DOI
10.1093/bbb/zbaa055