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Title

Localized Ca[sup2 ] uncaging reveals polarized distribution of Ca[sup2 ]-sensitive Ca[sup2 ] release sites: mechanism of unidirectional Ca[sup2 ] waves.

Authors

Ashby, Michael C.; Craske, Madeleine; Myoung Kyu Park; Gerasimenko, Oleg V.; Burgoyne, Robert D.; Petersen, Ole H.; Tepikin, Alexei V.

Abstract

Investigates the calcium[sup2 ]-induced calcium[sup2 ] release (CICR) sensitivity of different regions of intact pancreatic acinar cells. Demonstrations of CICR sensitivity in local uncaging of caged calcium[sup2 ]; Role of CICR in the generation of cytosolic calcium signals in cells; Properties of CICR.

Subjects

CALCIUM; PANCREATIC acinar cells; CYTOSOL

Publication

Journal of Cell Biology, 2002, Vol 158, Issue 2, p283

ISSN

0021-9525

Publication type

Academic Journal

DOI

10.1083/jcb.200112025

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