Results
Title

Synthesis and Biological Evaluation of a Series of New Cyclohexenyl Nucleosides.

Authors

Gu, Ping; Morral, Jordi; Wang, Jing; Rozenski, Jef; Busson, Roger; Van Aerschot, Arthur; De Clercq, Erik; Herdewijn, Piet

Abstract

A series of cyclohexenyl nucleosides (1–8) were successfully prepared with moderate yield and their cytotoxicity and antiviral activity were investigated. Among the eight new compounds, only the diaminopurine analogue 8 showed pronounced activity against HSV-1, HSV-2.

Subjects

NUCLEOSIDES; HERPES simplex virus; ANTIVIRAL agents; PURINES; VIRUSES

Publication

Nucleosides, Nucleotides & Nucleic Acids, 2003, Vol 22, Issue 5-8, p845

ISSN

1525-7770

Publication type

Academic Journal

DOI

10.1081/NCN-120022668