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- Title
DNA TRIPLE-HELIX FORMATION AT PYRIMIDINE-PURINE INVERSION SITES.
- Authors
Parel, SergeP.; Marfurt, Judith; Leumann, ChristianJ.
- Abstract
A systematic investigation of a series of triplex forming oligonucleotides (TFOs) containing α-, and β- thymidine, α- and β-N7-hypoxanthine, and α- and β- N7 and N9 aminopurine nucleosides, designed to bind to T-A inversion sites in DNA target sequences was performed. Data obtained from gel mobility assays indicate that T-A recognition in the antiparallel triple-helical binding motif is possible if the nucleoside αN9-aminopurine is used opposite to the inversion site in the TFO.
- Subjects
OLIGONUCLEOTIDES; THYMIDINE; ADENINE; NUCLEOSIDES; DNA
- Publication
Nucleosides, Nucleotides & Nucleic Acids, 2001, Vol 20, Issue 4-7, p411
- ISSN
1525-7770
- Publication type
Academic Journal
- DOI
10.1081/NCN-100002315