DNA TRIPLE-HELIX FORMATION AT PYRIMIDINE-PURINE INVERSION SITES.

Parel, SergeP.; Marfurt, Judith; Leumann, ChristianJ.

A systematic investigation of a series of triplex forming oligonucleotides (TFOs) containing α-, and β- thymidine, α- and β-N7-hypoxanthine, and α- and β- N7 and N9 aminopurine nucleosides, designed to bind to T-A inversion sites in DNA target sequences was performed. Data obtained from gel mobility assays indicate that T-A recognition in the antiparallel triple-helical binding motif is possible if the nucleoside αN9-aminopurine is used opposite to the inversion site in the TFO.

OLIGONUCLEOTIDES; THYMIDINE; ADENINE; NUCLEOSIDES; DNA

Nucleosides, Nucleotides & Nucleic Acids, 2001, Vol 20, Issue 4-7, p411

1525-7770

Academic Journal

10.1081/NCN-100002315