Evaluation of the specificity of the 2023 European Society of Cardiology classification for infective endocarditis.

Moisset, Hugo; Rio, Julien; Suc, Gaspard; Benhard, Johan; Arnoult, Florence; Deconinck, Laurene; Grall, Nathalie; Iung, Bernard; Lescure, Francois-Xavier; Rouzet, François; Hoen, Bruno; Duval, Xavier; Hobson, Claire Amaris

Background: The 2023 Duke-ISCVID and 2023 ESC classifications have recently issued independent diagnostic criteria for infective endocarditis (IE), updating the 2015 ESC criteria. Objectives: The specificity of the 2023 ESC criteria should be evaluated and compared to the two other classifications in IE suspected patients. Methods: We retrospectively collected the characteristics of patients hospitalised in Bichat University Hospital, in 2021, who had been evaluated for suspicion of IE, and in whom IE diagnosis was finally rejected. All were classified by 2015 ESC, 2023 Duke-ISCVID, and 2023 ESC. Results: In total 130 patients were analysed. Mean age was 62 years, 64.6% were male, 30.0% had prosthetic cardiac valve or valve repair, 16.2% had cardiac implanted electronic device, and 23.1% other cardiac conditions. Overall, 2, 5 and 5 patients were falsely classified as definite IE with the 2015 ESC, 2023 Duke-ISCVID and 2023 ESC criteria, respectively. The corresponding specificities were 99% (95% CI [94%; 100%], 96% (95% CI [91%; 99%]), and 96% (95% CI [91%; 99%]). Conclusion: The 2023 ESC and the 2023 Duke-ISCVID criteria are highly specific, although slightly less than the 2015 ESC criteria, for ruling out the diagnosis of definite IE. HIGHLIGHTS: 2023 Duke-ISCVID and 2023 ESC criteria are recently issued diagnostic classifications 2023 ESC criteria have an excellent specificity, equivalent to the 2023 Duke-ISCVID one 2023 ESC criteria and the 2023 Duke-ISCVID are less specific than the 2015 ESC criteria Specificities were quite similar according to the nature of the cardiac valve (native or prosthetic valve) or the duration of antibiotic therapy

HEART valves; INFECTIVE endocarditis; ARTIFICIAL implants; ELECTRONIC equipment; UNIVERSITY hospitals

Infectious Diseases, 2024, Vol 56, Issue 12, p1102

2374-4235

Academic Journal

10.1080/23744235.2024.2412155