Title: Wobble uridine tRNA modification: a new vulnerability of refractory melanoma.
Authors: Rapino, Francesca; Close, Pierre
Abstract: The enzymes catalysing the modification of the wobble uridine (U34) of tRNAs (U34-enzymes) play an important role in tumor development. We have recently demonstrated that the U34-enzymes are crucial in the survival of glycolytic melanoma cultures through a codon-specific regulation of HIF1α mRNA translation. Moreover, depletion of U34-enzymes resensitizes resistant melanoma to targeted therapy. These results indicate that targeting U34-enzymes represents a new therapeutic opportunity for melanoma patients.
Subjects: MELANOMA; RADIOENZYMATIC assays; NEUROENDOCRINE tumors; BIOCATALYSIS; PROTEINS; ABNORMAL proteins
Publication: Molecular & Cellular Oncology, 2018, Vol 5, Issue 6, p1
ISSN: 2372-3556
Publication type: Academic Journal
DOI: 10.1080/23723556.2018.1513725

Wobble uridine tRNA modification: a new vulnerability of refractory melanoma.

Rapino, Francesca; Close, Pierre