Title: Schweinfurthiamide, a new alkaloid isolated from the tuber roots of Asparagus flagellaris Baker (Liliaceae).
Authors: Kamdeu, Elodie Nguelami; Menye Nomo, Adèle Nicaise; Tchoukoua, Abdou; Ngomo, Orleans; Djimeli Douanla, Pascal; Tchuendem Kenmogne, Marguerite Hortence; Shiono, Yoshihito; Tabopda, Turibio Kuiate
Abstract: The phytochemical investigations of the tuber roots of Asparagus flagellaris led to the isolation of a new alkaloid, schweinfurthiamide (1) and eight known compounds. The structures of the isolated compounds were elucidated using spectroscopic techniques 1D and 2D NMR (1H, 13C, COSY, HMBC, HMQC, HSQC-TOCSY). The absolute configuration of 1 was unambiguously determined using DP4 calculations. Compound 1 showed significant cytotoxicity against MCF-7 (breast cancer), NCI-H460 (lung cancer), and Hela (cervical cancer) cancer cell lines with IC50 values of 1.18 ± 0.02 µM, 2.25 ± 0.19 µM, and 4.23 ± 0.26 µM, respectively and no toxicity against normal human fibroblast (BJ).
Subjects: CYTOTOXINS; LUNG cancer; TUBERS; BREAST cancer; CERVICAL cancer
Publication: Natural Product Research, 2025, Vol 39, Issue 1, p144
ISSN: 1478-6419
Publication type: Academic Journal
DOI: 10.1080/14786419.2023.2257358

Schweinfurthiamide, a new alkaloid isolated from the tuber roots of Asparagus flagellaris Baker (Liliaceae).

Kamdeu, Elodie Nguelami; Menye Nomo, Adèle Nicaise; Tchoukoua, Abdou; Ngomo, Orleans; Djimeli Douanla, Pascal; Tchuendem Kenmogne, Marguerite Hortence; Shiono, Yoshihito; Tabopda, Turibio Kuiate