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Title

Isolation and in-silico approach of Modified Embelin derivative from Embelia ribes fruits as anti‐Alzheimer agent.

Authors

Rupesh, R.; Mohankumar, R; Sabarathinam, Sarvesh

Abstract

Embelin is one of the primary compounds present in the Embelia ribes fruit. Embelin has a broader pharmacological activity such as Anti-inflammatory, anti-bacterial, antioxidant, and many more. The ultimate aim of the study is to ensure the impact of reduced embelin in the management of Alzheimer's disease. Embelin was isolated and modified by the reduction method, and the Modified Embelin derivative (MED) 3-Undecylcyclohexa-2,5-diene-1,2,4,5-tetraol was analysed through FT-IR, NMR, and Mass Spectroscopic techniques. MED was docked against acetylcholinesterase (AChE) amyloid beta (Aβ) receptors PDB ID: 1EVE & 1B68, respectively. The docking scores remain similar to that of positive standards galantamine and Donepezil.

Subjects

ALZHEIMER'S disease; MOLECULAR docking; GALANTHAMINE; ACETYLCHOLINESTERASE; ANTI-inflammatory agents

Publication

Natural Product Research, 2025, Vol 39, Issue 1, p208

ISSN

1478-6419

Publication type

Academic Journal

DOI

10.1080/14786419.2023.2255920

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