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Title: Isolation and in-silico approach of Modified Embelin derivative from Embelia ribes fruits as anti‐Alzheimer agent.
Authors: Rupesh, R.; Mohankumar, R; Sabarathinam, Sarvesh
Abstract: Embelin is one of the primary compounds present in the Embelia ribes fruit. Embelin has a broader pharmacological activity such as Anti-inflammatory, anti-bacterial, antioxidant, and many more. The ultimate aim of the study is to ensure the impact of reduced embelin in the management of Alzheimer's disease. Embelin was isolated and modified by the reduction method, and the Modified Embelin derivative (MED) 3-Undecylcyclohexa-2,5-diene-1,2,4,5-tetraol was analysed through FT-IR, NMR, and Mass Spectroscopic techniques. MED was docked against acetylcholinesterase (AChE) amyloid beta (Aβ) receptors PDB ID: 1EVE & 1B68, respectively. The docking scores remain similar to that of positive standards galantamine and Donepezil.
Subjects: ALZHEIMER'S disease; MOLECULAR docking; GALANTHAMINE; ACETYLCHOLINESTERASE; ANTI-inflammatory agents
Publication: Natural Product Research, 2025, Vol 39, Issue 1, p208
ISSN: 1478-6419
Publication type: Academic Journal
DOI: 10.1080/14786419.2023.2255920

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Isolation and in-silico approach of Modified Embelin derivative from Embelia ribes fruits as anti‐Alzheimer agent.