Sesquiterpenoids from the whole plants of Elephantopus mollis with cytotoxicity activities.

Lin, Qiang; Du, Jing-Yi; Yang, Si-Yu; Zhan, Zhao-Chun; Tang, Qing; Sun, Hui; Tan, Jin-Lin; Zhao, Hai-Yue; Li, Yao-Lan; Zhang, Yu-Bo; Wang, Guo-Cai

Five new sesquiterpenoids (1-5), elephantmollides A-E, along with four known compounds (6-9), were isolated from the whole plants of E. mollis. Their planar structures were elucidated using the spectroscopic methods, including HRESIMS, IR, UV, and NMR (1H, 13C, DEPT, HSQC, HMBC, 1H-1H COSY). The relative configurations of them were partially deduced by the NOESY experiment, and the absolute configurations were assigned by comparing the calculated electronic circular dichroism (ECD) results with the experimental data. In addition, cytotoxic activities of 1-9 against HepG2 cells ware tested, and compounds 1-9 exhibited cytotoxic activities with IC50 values ranging from 6.7 to 25.8 μM.

SESQUITERPENES; CYTOTOXINS; CIRCULAR dichroism

Natural Product Research, 2025, Vol 39, Issue 1, p110

1478-6419

Academic Journal

10.1080/14786419.2023.2254456