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- Title
Sesquiterpenoids from the whole plants of Elephantopus mollis with cytotoxicity activities.
- Authors
Lin, Qiang; Du, Jing-Yi; Yang, Si-Yu; Zhan, Zhao-Chun; Tang, Qing; Sun, Hui; Tan, Jin-Lin; Zhao, Hai-Yue; Li, Yao-Lan; Zhang, Yu-Bo; Wang, Guo-Cai
- Abstract
Five new sesquiterpenoids (1-5), elephantmollides A-E, along with four known compounds (6-9), were isolated from the whole plants of E. mollis. Their planar structures were elucidated using the spectroscopic methods, including HRESIMS, IR, UV, and NMR (1H, 13C, DEPT, HSQC, HMBC, 1H-1H COSY). The relative configurations of them were partially deduced by the NOESY experiment, and the absolute configurations were assigned by comparing the calculated electronic circular dichroism (ECD) results with the experimental data. In addition, cytotoxic activities of 1-9 against HepG2 cells ware tested, and compounds 1-9 exhibited cytotoxic activities with IC50 values ranging from 6.7 to 25.8 μM.
- Subjects
SESQUITERPENES; CYTOTOXINS; CIRCULAR dichroism
- Publication
Natural Product Research, 2025, Vol 39, Issue 1, p110
- ISSN
1478-6419
- Publication type
Academic Journal
- DOI
10.1080/14786419.2023.2254456