Title: Two new naphthoquinone derivatives from Sinningia conspicua (Gesneriaceae).
Authors: Winiewski, Vanessa; Verdan, Maria Helena; Santos Oliveira, Cristhian; Eloyane Barreto Rodrigues, Tayná; Salvador, Marcos José; Alves Stefanello, Maria Élida
Abstract: Two new naphthoquinones, 7-hydroxy-2-O-methyldunniol (1) and 7-methoxy-2-O-methyldunniol (2) were isolated from the tubers of Sinningia conspicua (Seem.) G. Nicholson (Gesneriaceae). Nine known compounds were also obtained: 7-methoxydunniol (3), dunniol (4), 7-methoxy-α-dunnione (5), 7-hydroxydunnione (6), 2,4,4',6-tetramethoxychalcone (7), loureirin B (8), allo-calceolarioside A (9), β-sitosterol (10) and stigmasterol (11). This is the first report of compounds 3 and 5 in Sinningia. n-Hexane, ethyl acetate and ethanol extracts, and compounds 1–5 were tested for cytotoxic activity against PC-3 (prostate) and SKMEL 103 (melanoma) human tumour cell lines and also against the 3T3 (fibroblast) non-cancer cell line. All samples were inactive.
Subjects: GESNERIACEAE; ETHYL acetate; CELL lines; DIHYDROCHALCONES; TUBERS
Publication: Natural Product Research, 2025, Vol 39, Issue 1, p88
ISSN: 1478-6419
Publication type: Academic Journal
DOI: 10.1080/14786419.2023.2253971

Two new naphthoquinone derivatives from Sinningia conspicua (Gesneriaceae).

Winiewski, Vanessa; Verdan, Maria Helena; Santos Oliveira, Cristhian; Eloyane Barreto Rodrigues, Tayná; Salvador, Marcos José; Alves Stefanello, Maria Élida