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- Title
5-nitro isatin containing heterocyclics derivatives: synthesis, antioxidant activity, anticancer activity and molecular docking.
- Authors
Ayad Mohamed Rasheed, Hala; Al-Majidi, Suaad M. H.
- Abstract
The manuscript describes the synthesis of eight Novel 1,2,4-triazine and 1,2-diazino derivatives having the 5-nitro isatin moiety. Antiradical and anticancer activities were evaluated using the DPPH method and the MTT assay against breast cancer (MCF-7) cell lines. The compound with the strongest antioxidant and anticancer properties after 24 h was compound 9 (1,2,4-triazine-3-thione) but after 48 h, compound 7 (1,2,4- triazine-3-ol) with good anticancer activity while compound 11 (1,2-diazino) after 72 h.
- Subjects
ANTINEOPLASTIC agents; ISATIN; MOLECULAR docking; PYRIDAZINES; BREAST cancer
- Publication
Natural Product Research, 2025, Vol 39, Issue 1, p56
- ISSN
1478-6419
- Publication type
Academic Journal
- DOI
10.1080/14786419.2023.2250898