New indole alkaloid Morucolletotricin from endophytic fungus Colletotrichum queenslandicum associated with Morus australis Poir. Leaf.

Ningsih, Kurnia Nastira; Hakim, Euis Holisotan

Six compounds were isolated from the ethyl acetate extract of endophytic fungus Colletotrichum queenslandicum derived from Morus australis Poir. leaf. Based on NMR and MS data led to characterised of these compounds including one new indole alkaloid Morucolletotricin (1) along with two other indole alkaloids; tryptopol (2) and indole-3-acetic acid (3), phomopyronol (4), 2-(3-aminophenyl)acetic acid (5) and ergosterol (6). phomopyronol (4) and 2-(3-aminophenyl)acetic acid (5) were first reported from Colletotrichum fungi. The cytotoxic activity of compounds 1-6 was evaluated against murine leukaemia P-388 cells and showed that all compounds were moderate cytotoxic. phomopyronol (4) was the most active among the five other compounds with IC50 = 37.17 μg/mL.

INDOLE alkaloids; ENDOPHYTIC fungi; ACETIC acid; ETHYL acetate; COLLETOTRICHUM

Natural Product Research, 2025, Vol 39, Issue 1, p202

1478-6419

Academic Journal

10.1080/14786419.2023.2250520