Results
Title

A new anti-neuroinflammation labdane diterpenoid from Salvia tricuspis.

Authors

Xie, Lu; Zhang, Xiu-Juan; Wang, Ying; Shi, Ye-Fan; Wang, Pan-Pan; Zagal, Daniel; Li, Chun-Huan

Abstract

One new labdane diterpenoid, tricuspion A (1), as well as five known triterpenoids (2–6) were isolated from Salvia tricuspis Franch (family Labiatae). The structure of tricuspion A was identified by extensive spectroscopic analysis and by comparison with previously reported data. Compounds 1–6 were evaluated for their inhibitory effects on the NO production in LPS-stimulated BV-2 microglia cells, and 1 exhibited potent inhibitory activity with IC50 value of 14.92 ± 0.51 μM. Compound 1 might exert anti-neuroinflammatory activity through inhibiting the excessive production of NO and down-regulating the protein expression of iNOS and COX-2. As such, labdane diterpenoid (tricuspion A) could provide promising anti-neuroinflammatory lead compound for further structural modification.

Subjects

NITRIC-oxide synthases; PROTEIN expression; SALVIA; LAMIACEAE; CYCLOOXYGENASE 2

Publication

Natural Product Research, 2025, Vol 39, Issue 1, p39

ISSN

1478-6419

Publication type

Academic Journal

DOI

10.1080/14786419.2023.2248541