Title: Miliutine A acid, a new cyclofarnesane sesquiterpene from the stems of Miliusa velutina.
Authors: Le, Hoang Khang; Phan, Thanh Tung; Loan Vo, Thi Kieu; Duong Ngo, Thi Thuy; Ngo, Hoang Long; Hansen, Poul Erik; That, Quang Ton
Abstract: Six compounds were isolated from the ethyl acetate extract of the stems of Miliusa velutina, including miliutine A acid (1), a new cyclofarnesane sesquiterpenoid; miliutine B methyl ester (2), a cyclofarnesane sesquiterpenoid which was determined the absolute configuration for the first time and four known phenol derivatives (3–6). NMR spectroscopic and mass spectrometry were used for identifying relative configurations. The assignments of the absolute configurations were determined based on Electronic Circular Dichroism (ECD) and NOESY spectra analysis. All six compounds were screened for their in vitro cytotoxic activities against HepG2 cell line using the SRB assay and they showed weak or none activities.
Subjects: PHENOL derivatives; METHYL formate; ETHYL acetate; CIRCULAR dichroism; SPECTRUM analysis
Publication: Natural Product Research, 2025, Vol 39, Issue 1, p31
ISSN: 1478-6419
Publication type: Academic Journal
DOI: 10.1080/14786419.2023.2248540

Miliutine A acid, a new cyclofarnesane sesquiterpene from the stems of Miliusa velutina.

Le, Hoang Khang; Phan, Thanh Tung; Loan Vo, Thi Kieu; Duong Ngo, Thi Thuy; Ngo, Hoang Long; Hansen, Poul Erik; That, Quang Ton