Results
Title

Two new 30-norfriedelane triterpenes from Caloncoba glauca (P. Beauv.) Gilg (Achariaceae).

Authors

Ndoumbe Tamba, Charlemagne; Tsopgni, Willifred Dongmo Tekapi; Fotso, Bernard Samuel Hodjie; Longue Ekon, Jean Pierre; Foundikou Nsangou, Mohamed; Ngo Nyobe, Judith Caroline; Sewald, Norbert; Ndom, Jean Claude

Abstract

The chemical investigation of the methanolic root extract of Caloncoba glauca (P. Beauv.) Gilg exhibited two new 30-norfriedelane triterpenes, glaucalactones A and B (1–2), together with eight known compounds, caloncobalactone (3), friedelin (4), friedelanol (5), 3-oxo-friedelan-28-oic acid (6), stigmasterol (7), β-sitosterol (8), β-sitosterol-3-O-β-D-glucopyranoside (9) and pentacosanoic acid (10). The structures of the isolates were elucidated by extensive spectroscopic and spectrometric analyses (1D and 2D NMR, ESI-MS) and by comparison with previously reported data. All the compounds were tested for their antioxidant, antifungal and antibacterial activities. Compound 1 displayed weak antibacterial effect with MIC value of 125 μg/mL against Staphylococcus aureus and Escherishia coli. Compound 6 exhibited moderated antifungal activity against Candida krusei with MIC value of 62.5 μg/mL. All the isolates were found to be inactive as antioxidants in the DPPH, ABTS and FRAP assays.

Subjects

PLANT extracts; ANTIOXIDANT testing; ANTIBACTERIAL agents; TRITERPENES; STAPHYLOCOCCUS aureus

Publication

Natural Product Research, 2025, Vol 39, Issue 1, p9

ISSN

1478-6419

Publication type

Academic Journal

DOI

10.1080/14786419.2023.2248351