We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Preussiate, a new urease inhibitory chalcone from Dioscorea preussii Pax.
- Authors
Ali, Muhammad Shaiq; Iqbal, Seerat; Lateef, Mehreen; Joseph, Ngoupayo
- Abstract
The phytochemical investigation of the aqueous methanolic extract of the aerial parts of Dioscorea preussii, led to the isolation of a new chalcone preussiate (1) along with 10 other compounds including xanthomicrol (2), cholestan-3-one (3), arjunolic acid (4), tormentic acid (5), ursolic acid (6), betulin (7), lupeol (8), p-hydroxybenzoic acid (9), isovanillin (10) and vanillic acid (11), being reported for the first time from this plant. Their structures were established by spectroscopic techniques including 2D NMR spectroscopy. All the isolates were subjected to the biological screening but only showed antioxidant and urease inhibitory properties. The compounds 1,8 and 11 displayed the most potent urease inhibitory properties with IC50 values, 22.4, 33.3 and 35.7 µM, respectively, while 3 was moderately active. The compound 11 showed potent antioxidant activity among all the tested isolates with an IC50 value of 45.3 µM.
- Subjects
URSOLIC acid; NUCLEAR magnetic resonance spectroscopy; CHALCONE; YAMS; UREASE
- Publication
Natural Product Research, 2025, Vol 39, Issue 1, p1
- ISSN
1478-6419
- Publication type
Academic Journal
- DOI
10.1080/14786419.2023.2248350