Title: Two new amides from the seeds of Coix lacryma-jobi var. lacryma-jobi.
Authors: Yin, Xin; Zhu, Wei-qian; Zhou, Yong-qiang; Hu, Rui-hang; Wei, Xin; Feng, Ting-ting; Zhou, Ying
Abstract: Phytochemical investigation of the seeds of Coix lacryma-jobi var. lacryma-jobi resulted in the isolation of eight compounds, including two new structures, coixdines A-B (1-2) and six known compounds (3-8). The structures of these compounds were determined by 1 D and 2 D NMR spectra referring to the literatures, together with HR-MS analysis. Coixdine A and B are first examples of spermidine skeleton in genus Coix. In the present paper, all compounds were evaluated for the cytotoxicity against two cancer cell lines (CT-26 and BxPC-3) in vitro, and none of the compounds exhibited obvious cytotoxic activity. The present investigation suggests that these amides seem to be of great chemotaxonomic value for C. lacryma-jobi.
Subjects: AMIDES; SEEDS; SPERMIDINE; CELL lines; CANCER cells; COLE crops
Publication: Natural Product Research, 2023, Vol 37, Issue 20, p3499
ISSN: 1478-6419
Publication type: Academic Journal
DOI: 10.1080/14786419.2022.2089669

Two new amides from the seeds of Coix lacryma-jobi var. lacryma-jobi.

Yin, Xin; Zhu, Wei-qian; Zhou, Yong-qiang; Hu, Rui-hang; Wei, Xin; Feng, Ting-ting; Zhou, Ying