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- Title
Cytotoxic sesquiterpene lactones and lignans from Cousinia turkmenorum Bornm (Asteraceae).
- Authors
Norouzi, Saeed; Iranshahy, Milad; Iranshahi, Mehrdad; Shakeri, Abolfazl
- Abstract
Seven sesquiterpene lactones, chlorophyssopifolin E (1), aguerin B (2), repdiolide triol (3), solistitiolide (4), aitchisonolide (5), sinicin B (6), cynaropicrin (7), along with four lignans arctigenin (8), arctiin (9), matairesinol (10), and matairesinoside (11) were isolated for the first time from the aerial parts of Cousinia turkmenorum Bornm. Among the isolated compounds, aguerin B (2) showed the most cytotoxic activity against MCF7 cell lines with IC50 value of 18.9 μM. Findings of this study could be useful for the development of new anticancer agents from nature.
- Subjects
SESQUITERPENE lactones; LIGNANS; ASTERACEAE; CELL lines; ANTINEOPLASTIC agents
- Publication
Natural Product Research, 2022, Vol 36, Issue 23, p6096
- ISSN
1478-6419
- Publication type
Academic Journal
- DOI
10.1080/14786419.2022.2045984