Title: Cytotoxic sesquiterpene lactones and lignans from Cousinia turkmenorum Bornm (Asteraceae).
Authors: Norouzi, Saeed; Iranshahy, Milad; Iranshahi, Mehrdad; Shakeri, Abolfazl
Abstract: Seven sesquiterpene lactones, chlorophyssopifolin E (1), aguerin B (2), repdiolide triol (3), solistitiolide (4), aitchisonolide (5), sinicin B (6), cynaropicrin (7), along with four lignans arctigenin (8), arctiin (9), matairesinol (10), and matairesinoside (11) were isolated for the first time from the aerial parts of Cousinia turkmenorum Bornm. Among the isolated compounds, aguerin B (2) showed the most cytotoxic activity against MCF7 cell lines with IC50 value of 18.9 μM. Findings of this study could be useful for the development of new anticancer agents from nature.
Subjects: SESQUITERPENE lactones; LIGNANS; ASTERACEAE; CELL lines; ANTINEOPLASTIC agents
Publication: Natural Product Research, 2022, Vol 36, Issue 23, p6096
ISSN: 1478-6419
Publication type: Academic Journal
DOI: 10.1080/14786419.2022.2045984

Cytotoxic sesquiterpene lactones and lignans from Cousinia turkmenorum Bornm (Asteraceae).

Norouzi, Saeed; Iranshahy, Milad; Iranshahi, Mehrdad; Shakeri, Abolfazl