We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Rapid determination and optimisation of berberine from Himalayan Berberis lycium by soxhlet apparatus using CCD-RSM and its quality control as a potential candidate for COVID-19.
- Authors
Katare, Anil Kumar; Singh, Bikarma; Shukla, Pooja; Gupta, Sandeep; Singh, Bishander; Yalamanchili, Kavya; Kulshrestha, Nitin; Bhanwaria, Rajendra; Sharma, Ashok Kumar; Sharma, Sarita; Sneha; Mindala, Durga Prasad; Roy, Sumit; Kalgotra, Rahul
- Abstract
SARS-CoV-2 (or COVID-19) has become a global risk and scientists are attempting to investigate antiviral vaccine. Berberis are important plants due to the presence of bioactive phytochemicals, especially berberine from the protoberberine group of benzylisoquinoline and recent studies have shown its potential in treating COVID-19. B. lycium Royle growing in subtropical regions of Asia had wide applications in Indian system of medicine. Rapid determination and novel optimisation method for berberine extraction has been developed by Soxhlet extraction utilising central composite design-response surface methodology (CCD-RSM). Berberine was detected by high-performance liquid chromatography (HPLC), and the highest yield (13.39%) was obtained by maintaining optimal extraction conditions i.e., extraction time (7.28 hrs), ethyl alcohol (52.21%) and solvent to sample ratio (21.78 v/w). Investigation of two geographic regions (Ramnagar and Srinagar) showed high berberine content in lower altitude. This novel optimisation technique has placed berberine as a potential candidate for developing pharmaceutical products for human health care.
- Subjects
ASIA; BERBERINE; QUALITY control; HIGH performance liquid chromatography; BARBERRIES; COVID-19
- Publication
Natural Product Research, 2022, Vol 36, Issue 3, p868
- ISSN
1478-6419
- Publication type
Academic Journal
- DOI
10.1080/14786419.2020.1806274