Chemical composition and antioxidant activity of the essential oil of Alseodaphne velutina Chev. (Lauraceae) were investigated for the first time from Viet Nam. Leaf essential oil was hydrodistilled and analysed by GC and GC-MS that totally identified 32 terpenoid compounds (accouting for 89.18% of the total oil) with β-patchoulene (25.74%) and β-caryophyllene (12.81%) as two major sesquiterpene hydrocarbons compounds. The antioxidant potential of leaf essential oil was evaluated using DPPH, ABTS and FRAP assays, and revealed a moderate-to-high activity comparable with already known antioxidant standard Trolox.