Chemical constituents from common vetch (Vicia sativa L.) and their antioxidant and cytotoxic activities.

Liu, Li-Fang; Li, Wen-Hai; Li, Man-Yu; Wu, Xiao-Zhen; Yang, Fan; Xu, Jia-Nan; Yuan, Cheng-Shan

Vicia sativa L. (common vetch) is a potential food source for both human beings and animals because of its abundant nutritional composition. There is a lack of phytochemical study on the whole plant, and thus the objective of this study was to investigate the isolation of phytochemicals and evaluate their biological activities. A new flavanol, (2R,3S)-3,3′-dihydroxy-4′,7-dimethoxyflavanol (1), together with nine known compounds, two flavones (2–3), one coumarin (4), and six oleanane triterpenoids (5–10), was obtained from Vicia sativa L.. The structure of the new compound 1 was determined via its NMR spectra, IR and CD data. Compound 3 displayed the potential of the DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging effect in antioxidant test. In terms of cytotoxic activities, compound 3 showed moderate cytotoxic activities against three human tumor cells, especially HeLa cells.

VETCH; COUMARINS; ANTIOXIDANT testing; HELA cells; HUMAN beings; TRITERPENOIDS

Natural Product Research, 2020, Vol 34, Issue 22, p3205

1478-6419

Academic Journal

10.1080/14786419.2018.1560282