Title: Lactoquinomycin C and D, two new medermycin derivatives from the marine-derived Streptomyces sp. SS17A.
Authors: Zhou, Biao; Jiang, Yong-Jun; Ji, Yuan-Yuan; Zhang, Hao-Jian; Shen, Li
Abstract: Lactoquinomycin C (1) and Lactoquinomycin D (2), two new medermycin derivatives together with six known compounds (3–8) were isolated from the rice solid fermentation of the marine-derived Streptomyces sp. SS17A. The intriguing structural features of the Lactoquinomycin D (2) which contains 5,14-epoxidation is relatively rare in medermycin derivatives. Compounds 1 and 2 exhibited no cytotoxicity against PC-3 and HCT-116 cancer cell lines, whereas compound 3 showed stronger cytotoxicity with IC50 values of 0.02 and 0.04 μM, respectively. A structure-activity relationship was observed for the cytotoxicity of the medermycin derivatives with a γ-lactone unit is required for significant cytotoxicity based on compounds 1–3.
Subjects: STREPTOMYCES; STRUCTURE-activity relationships; MARINE natural products; CELL lines; COUMARINS; CANCER cells; FERMENTATION
Publication: Natural Product Research, 2020, Vol 34, Issue 9, p1213
ISSN: 1478-6419
Publication type: Academic Journal
DOI: 10.1080/14786419.2018.1556265

Lactoquinomycin C and D, two new medermycin derivatives from the marine-derived Streptomyces sp. SS17A.

Zhou, Biao; Jiang, Yong-Jun; Ji, Yuan-Yuan; Zhang, Hao-Jian; Shen, Li