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- Title
Quassinoids from seeds of Brucea Javanica and their anticomplement activities.
- Authors
Zhan, Yanzhi; Tan, Ting; Qian, Kai; Yang, Shilin; Feng, Yulin; Wen, Quan
- Abstract
An investigation on seeds of Brucea javanica led to the acquisition of a new quassinoid, 20-hydroxyyadanzigan (1), along with five known quassinoids (2–6). The structure of the new compound was elucidated on the basis of extensive spectral analysis. All of the compounds were assayed for their anticomplement activities through classical and alternative pathways. Compounds 1–6 exhibited potent anticomplement activity with CH50 and AP50 values of 0.032–0.075 mg/mL and 0.061–0.118 mg/mL, respectively. Moreover, the structure-activity relationships of these compounds are discussed.
- Subjects
SEEDS; STRUCTURE-activity relationships; INVESTIGATIONS
- Publication
Natural Product Research, 2020, Vol 34, Issue 8, p1186
- ISSN
1478-6419
- Publication type
Academic Journal
- DOI
10.1080/14786419.2018.1550764