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- Title
A new isoflavone with anti-inflammatory effect from the seeds of Millettia pachycarpa.
- Authors
Tu, Yan-bei; Xiao, Tong; Gong, Gui-yi; Bian, Ya-qi; Li, Yan-fang
- Abstract
A new isoflavone, milletenol A (1), along with four known flavonoids (2–5) were isolated from the seeds of Millettia pachycarpa. The structure of 1 was established by extensive spectroscopic methods while known compounds were identified by comparisons with literature data. Compound 1 and 2 showed significant anti-inflammatory activities against nitric oxide production in LPS-induced RAW264.7 macrophages. The state of CuSO4-stimulated inflammation was effectively alleviated by compound 1 in zebrafish. However, no significant cytotoxicity against human breast cancer cells was observed among all isolates.
- Subjects
SEEDS; CANCER cells; NITRIC oxide; BREAST cancer; FLAVONOIDS
- Publication
Natural Product Research, 2020, Vol 34, Issue 7, p981
- ISSN
1478-6419
- Publication type
Academic Journal
- DOI
10.1080/14786419.2018.1547294