Title: A new isoflavone with anti-inflammatory effect from the seeds of Millettia pachycarpa.
Authors: Tu, Yan-bei; Xiao, Tong; Gong, Gui-yi; Bian, Ya-qi; Li, Yan-fang
Abstract: A new isoflavone, milletenol A (1), along with four known flavonoids (2–5) were isolated from the seeds of Millettia pachycarpa. The structure of 1 was established by extensive spectroscopic methods while known compounds were identified by comparisons with literature data. Compound 1 and 2 showed significant anti-inflammatory activities against nitric oxide production in LPS-induced RAW264.7 macrophages. The state of CuSO4-stimulated inflammation was effectively alleviated by compound 1 in zebrafish. However, no significant cytotoxicity against human breast cancer cells was observed among all isolates.
Subjects: SEEDS; CANCER cells; NITRIC oxide; BREAST cancer; FLAVONOIDS
Publication: Natural Product Research, 2020, Vol 34, Issue 7, p981
ISSN: 1478-6419
Publication type: Academic Journal
DOI: 10.1080/14786419.2018.1547294

A new isoflavone with anti-inflammatory effect from the seeds of Millettia pachycarpa.

Tu, Yan-bei; Xiao, Tong; Gong, Gui-yi; Bian, Ya-qi; Li, Yan-fang