We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
A rare diketopiperazine glycoside from marine-sourced Streptomyces sp. ZZ446.
- Authors
Chen, Sangluo; Zhang, Di; Chen, Mengxuan; Zhang, Zhizhen; Lian, Xiao-Yuan
- Abstract
Two diketopiperazines were isolated from a culture of the marine-derived actinomycete Streptomyces sp. ZZ446. Their structures were elucidated as maculosin (1) and maculosin-O-α-L-rhamnopyranoside (2) based on their NMR and HRESIMS data, specific rotation, and chemical degradation. Maculosin-O-α-L-rhamnopyranoside (2) is a new diketopiperazine glycoside, a structural class not reported previously from the natural sources. Both compounds showed antimicrobial activity against methicillin-resistant Staphylococcus aureus, Escherichia coli, and Candida albicans with MIC values in a range from 26.0 to 37.0 μg/mL.
- Subjects
STREPTOMYCES; METHICILLIN-resistant staphylococcus aureus; CHEMICAL decomposition; CANDIDA albicans; DIKETOPIPERAZINES
- Publication
Natural Product Research, 2020, Vol 34, Issue 7, p1046
- ISSN
1478-6419
- Publication type
Academic Journal
- DOI
10.1080/14786419.2018.1544978