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Title: Three new ɑ-pyrone derivatives induced by chemical epigenetic manipulation of Penicillium herquei, an endophytic fungus isolated from Cordyceps sinensis.
Authors: Guo, Da-Le; Qiu, Ling; Feng, Dan; He, Xin; Li, Xiao-Hua; Cao, Zhi-Xing; Gu, Yu-Cheng; Mei, Ling; Deng, Fang; Deng, Yun
Abstract: Chemical epigenetic manipulation was applied to explore secondary metabolite of an endophytic fungus Penicillium herquei, which was obtained from the fruiting body of Cordyceps sinensis, and three previously undescribed polyketides with pyran-2-one scaffold were isolated from its fermentation broth containing 10 mg/L 5-aza-2-deoxycytidine (a frequently-used DNA methyltransferase inhibitor). The structures of these new compounds were identified by extensive spectroscopic analyses, and their absolute configurations were elucidated by quantum chemical ECD calculations.
Subjects: ENDOPHYTIC fungi; CHEMICAL derivatives; CORDYCEPS; PENICILLIUM; DNA methyltransferases
Publication: Natural Product Research, 2020, Vol 34, Issue 7, p958
ISSN: 1478-6419
Publication type: Academic Journal
DOI: 10.1080/14786419.2018.1544974

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Three new ɑ-pyrone derivatives induced by chemical epigenetic manipulation of Penicillium herquei, an endophytic fungus isolated from Cordyceps sinensis.