We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
New cytotoxic bufadienolides from the roots and rhizomes of Helleborus thibetanus Franch.
- Authors
Li, Yuze; Zhang, Huawei; Liang, Xiaofei; Song, Bei; Zheng, Xudong; Wang, Rui; Liu, Li; Song, Xiaomei; Liu, Jianli
- Abstract
Three new bufadienolides 14β, 16β-dihydroxy-3β-[β-D-glucopyranosyl-(1→6)-(β-D-glucopyranosyl)oxy]-5α-bufa-20, 22-dienolide (1), 14β-hydroxy-3β-[β-D-glucopyranosyl-(1→4)-(β-D-glucopyranosyl)oxy]-5α-bufa-20, 22-dienolide (2) and hellebrigenin-3-O-β-D-glucosyl-(1→4)-β-D-glucoside (3), together with eight known bufadienolides (4–11) were isolated from the roots and rhizomes of Helleborus thibetanus. Their structures were elucidated by extensive spectroscopic methods and acid hydrolysis. Compounds 1–7 were evaluated for their cytotoxic activity against HCT116, A549 and HepG2 tumor cell lines. Compound 1 exhibited moderate cytotoxicity against HepG2 cells with IC50 value of 15.1 ± 1.72 μM. Compounds 5 and 6 exhibited moderate cytotoxicity against HCT116 cells with IC50 values of 15.12 ± 0.58 μM and 13.17 ± 2.34 μM, respectively.
- Subjects
HELLEBORES; CELL lines
- Publication
Natural Product Research, 2020, Vol 34, Issue 7, p950
- ISSN
1478-6419
- Publication type
Academic Journal
- DOI
10.1080/14786419.2018.1543687