Title: New cytotoxic bufadienolides from the roots and rhizomes of Helleborus thibetanus Franch.
Authors: Li, Yuze; Zhang, Huawei; Liang, Xiaofei; Song, Bei; Zheng, Xudong; Wang, Rui; Liu, Li; Song, Xiaomei; Liu, Jianli
Abstract: Three new bufadienolides 14β, 16β-dihydroxy-3β-[β-D-glucopyranosyl-(1→6)-(β-D-glucopyranosyl)oxy]-5α-bufa-20, 22-dienolide (1), 14β-hydroxy-3β-[β-D-glucopyranosyl-(1→4)-(β-D-glucopyranosyl)oxy]-5α-bufa-20, 22-dienolide (2) and hellebrigenin-3-O-β-D-glucosyl-(1→4)-β-D-glucoside (3), together with eight known bufadienolides (4–11) were isolated from the roots and rhizomes of Helleborus thibetanus. Their structures were elucidated by extensive spectroscopic methods and acid hydrolysis. Compounds 1–7 were evaluated for their cytotoxic activity against HCT116, A549 and HepG2 tumor cell lines. Compound 1 exhibited moderate cytotoxicity against HepG2 cells with IC50 value of 15.1 ± 1.72 μM. Compounds 5 and 6 exhibited moderate cytotoxicity against HCT116 cells with IC50 values of 15.12 ± 0.58 μM and 13.17 ± 2.34 μM, respectively.
Subjects: HELLEBORES; CELL lines
Publication: Natural Product Research, 2020, Vol 34, Issue 7, p950
ISSN: 1478-6419
Publication type: Academic Journal
DOI: 10.1080/14786419.2018.1543687

New cytotoxic bufadienolides from the roots and rhizomes of Helleborus thibetanus Franch.

Li, Yuze; Zhang, Huawei; Liang, Xiaofei; Song, Bei; Zheng, Xudong; Wang, Rui; Liu, Li; Song, Xiaomei; Liu, Jianli