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- Title
New nor-oleanane triterpenoids from the fruits of Stauntonia brachyanthera with potential anti-inflammation activity.
- Authors
Li, Jiaheng; Du, Kaicheng; Liu, Dan; Meng, Dali
- Abstract
The continuing studies on the fruits of Stauntonia brachyanthera led to the isolations of 6 normal and nor-oleanane triterpenoids, including two new compounds, brachyantheoraside B10 (1) and brachyantheraside C1 (2). Compounds 1–3 showed inhibitory activity on lipopolysaccharide (LPS)-induced nitric oxide production in RAW 264.7 macrophages with the IC50 values of 27.04, 26.22, and 21.41 μM, respectively, which were all stronger than that of indomethacin. The study not only revealed a new type of nor-oleanane triterpenoids, but also confirmed the anti-inflammation abilities of three type nor-oleanane triterpenoids as the inhibitors of NO production.
- Subjects
TRITERPENOIDS; FRUIT; NITRIC oxide
- Publication
Natural Product Research, 2020, Vol 34, Issue 7, p915
- ISSN
1478-6419
- Publication type
Academic Journal
- DOI
10.1080/14786419.2018.1540478