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- Title
Identification of anti-nociceptive constituents from the pollen of Typha angustifolia L. using effect-directed fractionation.
- Authors
Zeng, Guangyao; Wu, Zhaoquan; Cao, Wei; Wang, Yajing; Deng, Xu; Zhou, Yingjun
- Abstract
The pollen of T. angustifolia, also known as Pu huang in Chinese, has been used for treatment of stranguria, hematuria, dysmenorrhea, metrorrhagia and injuries in China for a long time. Extensive efforts have been directed toward its phytochemical and biological aspects. However, little is known about its anti-nociceptive implication and material basis. This work presented the investigation of the anti-nociceptive effect of Typhae Pollen using an effect-directed fractionation strategy, thereby leading to identification of isorhamnetin-3-O-neohesperidin (1) and typhaneoside (2), together with other minor flavonoid glycoside congeners, as the main anti-nociceptive constituents. This work not only unveils the anti-nociceptive potential of Typhae Pollen, but also establishes a method to enrich and identify the anti-nociceptive constitutes of Typhae Pollen. Moreover, this work is a successful example of effect-directed fractionation strategy, which represents a powerful tool in TCM-based drug discovery and development.
- Subjects
CHINA; POLLEN; TYPHA; FLAVONOID glycosides; DRUG development; IDENTIFICATION
- Publication
Natural Product Research, 2020, Vol 34, Issue 7, p1041
- ISSN
1478-6419
- Publication type
Academic Journal
- DOI
10.1080/14786419.2018.1539979