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- Title
Neogenkwanine I from the flower buds of Daphne genkwa with its stereostructure confirmation using quantum calculation profiles and antitumor evaluation.
- Authors
Hou, Xue-Wen; Han, Shuang; Zhang, Ying-Ying; Su, Hai-Bi; Gao, Pin-Yi; Li, Ling-Zhi; Song, Shao-Jiang
- Abstract
Neogenkwanine I (1), a new daphnane-type diterpene with 4,7-ether group, along with four known ones (2–5), were isolated from Daphne genkwa. The structure including absolute configurations of 1 was established on the basis of NMR, 13C-NMR and ECD calculations and CD exciton chirality analysis. 13C-NMR and ECD calculations of daphnane-type diterpenes were reported here for the first time. All of the diterpenes were screened for their cytotoxic activities against MCF-7 and Hep3B cell lines. The cytotoxicity structure- activity relationship of compounds was illustrated with the absence of ortho-ester group of daphnane-type diterpenes.
- Subjects
DITERPENES; BUDS; CELL lines; FLOWERS; STRUCTURE-activity relationships
- Publication
Natural Product Research, 2020, Vol 34, Issue 3, p405
- ISSN
1478-6419
- Publication type
Academic Journal
- DOI
10.1080/14786419.2018.1536133