Title: A new aliphatic ester of hydroxysalicylic acid from fermented Carica papaya L. preparation with a potential hair growth stimulating activity.
Authors: Ashour, Ahmed; Amen, Yhiya; Nakagawa, Toshinori; Niwa, Yasuharu; Mira, Amira; Ohnuki, Koichiro; Murakami, Shinki; Imao, Mitsuko; Shimizu, Kuniyoshi
Abstract: An aliphatic ester of hydroxysalicylic acid (6), reported for the first time from a natural source in addition to five known compounds were isolated from the fermented Carica papaya L. preparation, a commercialized functional food. The known compounds were identified as 5-hydroxymethylfurfuraldehyde (1), trans-caffeic acid (2), butyl 4-hydroxybenzoate (butylparaben) (3), lycopene (4), benzyl isothiocyanate (5). Compounds 1 and 3 were reported for the first time from Papaya fruits through this study. The new compound showed a moderate antioxidant activity and a potent hair growth stimulating activity in vitro.
Subjects: PAPAYA; HAIR growth; HAIR care products; MINOXIDIL; ESTERS; FUNCTIONAL foods
Publication: Natural Product Research, 2020, Vol 34, Issue 12, p1750
ISSN: 1478-6419
Publication type: Academic Journal
DOI: 10.1080/14786419.2018.1530231

A new aliphatic ester of hydroxysalicylic acid from fermented Carica papaya L. preparation with a potential hair growth stimulating activity.

Ashour, Ahmed; Amen, Yhiya; Nakagawa, Toshinori; Niwa, Yasuharu; Mira, Amira; Ohnuki, Koichiro; Murakami, Shinki; Imao, Mitsuko; Shimizu, Kuniyoshi