Antibacterial and cytotoxic activities of phenolic constituents from the stem extracts of Spatholobus parviflorus.

Promchai, Thanika; Janhom, Pawinee; Maneerat, Wisanu; Rattanajak, Roonglawan; Kamchonwongpaisan, Sumalee; Pyne, Stephen G.; Limtharakul, Thunwadee

A new 2-arylbenzofuran, spathobenzofuran (1), together with ten known compounds including a 2-arylbenzofuran, three pterocarpans and six isoflavones were isolated from the acetone crude extract of the stems of Spatholobus parviflorus. All compounds were characterised by spectroscopic methods. Compound 4 was active (MIC 8 µg/mL) against Gram-negative Pseudomonas aeruginosa TISTR 781 while compound 2 had modest activity against Gram-positive Staphylococcus aureus TISTR 1466 with a MIC value of 16 µg/mL. All isolated compounds showed no cytotoxicity against Vero and KB cells.

PSEUDOMONAS aeruginosa; EXTRACTS; STAPHYLOCOCCUS aureus; ISOFLAVONES; ACETONE

Natural Product Research, 2020, Vol 34, Issue 10, p1394

1478-6419

Academic Journal

10.1080/14786419.2018.1512990