EBSCO Logo
Connecting you to content on EBSCOhost
Results
Title

Design, synthesis and cholinesterase inhibitory activity of α-mangostin derivatives.

Authors

Chi, Xiao-Qian; Hou, Bo; Yang, Liu; Zi, Cheng-Ting; Lv, Yong-Feng; Li, Jin-Yu; Ren, Fu-Cai; Yuan, Ming-Yan; Hu, Jiang-Miao; Zhou, Jun

Abstract

α-mangostin, a polyphenol xanthone derivative, was mainly isolated from pericarps of the mangosteen fruit (Garcinia mangostana L.). In present investigation, a series of derivatives were designed, synthesised and evaluated in vitro for their inhibitory activity of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). Among the synthesised xanthones, compounds 1, 9, 13 and 16 showed AChE selective inhibitory activity, 15 was a BuChE selective inhibitor while 2, 3, 5, 6, 7, 12 and 14 were dual inhibitors. The most potent inhibitor of AChE was 16 while 5 was the most potent inhibitor of BuChE with IC50 values of 5.26 μM and 7.55 μM respectively.

Subjects

ACETYLCHOLINESTERASE; MANGOSTEEN; CHALCONE; CHOLINESTERASE inhibitors

Publication

Natural Product Research, 2020, Vol 34, Issue 10, p1380

ISSN

1478-6419

Publication type

Academic Journal

DOI

10.1080/14786419.2018.1510925

EBSCO Connect | Privacy policy | Terms of use | Copyright | Manage my cookies
Journals | Subjects | Sitemap
© 2025 EBSCO Industries, Inc. All rights reserved