We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Design, synthesis and cholinesterase inhibitory activity of α-mangostin derivatives.
- Authors
Chi, Xiao-Qian; Hou, Bo; Yang, Liu; Zi, Cheng-Ting; Lv, Yong-Feng; Li, Jin-Yu; Ren, Fu-Cai; Yuan, Ming-Yan; Hu, Jiang-Miao; Zhou, Jun
- Abstract
α-mangostin, a polyphenol xanthone derivative, was mainly isolated from pericarps of the mangosteen fruit (Garcinia mangostana L.). In present investigation, a series of derivatives were designed, synthesised and evaluated in vitro for their inhibitory activity of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). Among the synthesised xanthones, compounds 1, 9, 13 and 16 showed AChE selective inhibitory activity, 15 was a BuChE selective inhibitor while 2, 3, 5, 6, 7, 12 and 14 were dual inhibitors. The most potent inhibitor of AChE was 16 while 5 was the most potent inhibitor of BuChE with IC50 values of 5.26 μM and 7.55 μM respectively.
- Subjects
ACETYLCHOLINESTERASE; MANGOSTEEN; CHALCONE; CHOLINESTERASE inhibitors
- Publication
Natural Product Research, 2020, Vol 34, Issue 10, p1380
- ISSN
1478-6419
- Publication type
Academic Journal
- DOI
10.1080/14786419.2018.1510925