Design, synthesis and cholinesterase inhibitory activity of α-mangostin derivatives.

Chi, Xiao-Qian; Hou, Bo; Yang, Liu; Zi, Cheng-Ting; Lv, Yong-Feng; Li, Jin-Yu; Ren, Fu-Cai; Yuan, Ming-Yan; Hu, Jiang-Miao; Zhou, Jun

α-mangostin, a polyphenol xanthone derivative, was mainly isolated from pericarps of the mangosteen fruit (Garcinia mangostana L.). In present investigation, a series of derivatives were designed, synthesised and evaluated in vitro for their inhibitory activity of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). Among the synthesised xanthones, compounds 1, 9, 13 and 16 showed AChE selective inhibitory activity, 15 was a BuChE selective inhibitor while 2, 3, 5, 6, 7, 12 and 14 were dual inhibitors. The most potent inhibitor of AChE was 16 while 5 was the most potent inhibitor of BuChE with IC50 values of 5.26 μM and 7.55 μM respectively.

ACETYLCHOLINESTERASE; MANGOSTEEN; CHALCONE; CHOLINESTERASE inhibitors

Natural Product Research, 2020, Vol 34, Issue 10, p1380

1478-6419

Academic Journal

10.1080/14786419.2018.1510925