Title: Synthesis and structure anti-inflammatory activity relationships studies of andrographolide derivatives.
Authors: Liu, Ling; Yan, Yan; Zheng, Lihua; Jia, Haiyan; Han, Guang
Abstract: Andrographolide is a main bioactive diterpene lactone in A. paniculata with anti-inflammatory activity. In this study, a series of andrographolide derivatives were synthesized and evaluated for their structure-anti-inflammatory activity relationships in vivo. Among all compounds, isoandrographolide and 14-deoxyandrographolide showed stronger anti-inflammatory activity than andrographolide. The results indicated that the introduction of tetrahydrofuran ring and cyclic olefinic bond plays an important role in enhancing the anti-inflammatory activity of andrographolide derivatives. Isoandrographolide and 14-deoxyandrographolide are potent inhibitor of inflammation.
Subjects: STRUCTURE-activity relationships; DITERPENES
Publication: Natural Product Research, 2020, Vol 34, Issue 6, p782
ISSN: 1478-6419
Publication type: Academic Journal
DOI: 10.1080/14786419.2018.1501689

Synthesis and structure anti-inflammatory activity relationships studies of andrographolide derivatives.

Liu, Ling; Yan, Yan; Zheng, Lihua; Jia, Haiyan; Han, Guang