Results
Title

Two new phenolic compounds and some biological activities of Scorzonera pygmaea Sibth. & Sm. subaerial parts.

Authors

Şahin, Hasan; Sarı, Aynur; Özsoy, Nurten; Özbek Çelik, Berna; Koyuncu, Onur

Abstract

Phytochemical composition of ethyl acetate fraction and total phenolic content, in vitro antioxidant, anti-inflammatory, antimicrobial activities of petroleum ether, chloroform, ethyl acetate and n-butanol fractions of the ethanol extract obtained from the subaerial parts of Scorzonera pygmaea Sibth. & Sm. (Asteraceae) were investigated. Nine compounds; scorzopygmaecoside (1), scorzonerol (2), cudrabibenzyl A (3), thunberginol C (4), scorzocreticoside I (5) and II (6), chlorogenic acid (7), chlorogenic acid methyl ester (8), 3,5-di-O-caffeoylquinic acid (9) were isolated and identified using spectroscopic methods. All substances were isolated for the first time from this species. Compounds 1 and 2 are new. The fractions showed high antioxidant capacity correlated with their phenolic content and no significant antimicrobial activity against tested bacteria and fungi. COX inhibition test was used to evaluate the anti-inflammatory activity and all the fractions showed low inhibition in comparison with indomethacin.

Subjects

PHENOLS; CHLOROGENIC acid; ETHYL acetate; METHYL formate; OXIDANT status; PHENOL oxidase; PROPOLIS

Publication

Natural Product Research, 2020, Vol 34, Issue 5, p621

ISSN

1478-6419

Publication type

Academic Journal

DOI

10.1080/14786419.2018.1493585