We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Urease inhibitory potential of extracts and active phytochemicals of Hypochaeris radicata (Asteraceae).
- Authors
Abu-Izneid, Tareq; Rauf, Abdur; Saleem, Muhammad; Mansour, Nashwa; Abdelhady, Mohamed I. S.; Ibrahim, Munjed M.; Patel, Seema
- Abstract
Urease inhibition potential of compound (1), guaiane-type sesquiterpene (2), confertin (3) and scopoletin (4) was carried out with high throughout mechanism-based assay. These compounds were isolated from Hypochaeris radicata L., an Asteraceae family member. The pure compounds were screened for their urease and carbonic anhydrase inhibitory activities. The ethyl acetate fractions were subjected to column chromatography, which resulted in the isolation and purification of four compounds (1-4). On evaluation, compounds (1-4) exhibited selective activity against urease enzyme with an IC50 value of 180.11 ± 2.00, 27.18 ± 0.80, 24.12 ± 0.2 and 30.12 ± 1.10 mM respectively. The compounds (1-4) were found to be inactive against carbonic anhydrase enzyme. Thiourea was used as standard inhibitor (21 ± 0.14 mM) of urease
- Subjects
UREASE; CARBONIC anhydrase; BENZENESULFONAMIDES; PHYTOCHEMICALS; ASTERACEAE; COLUMN chromatography
- Publication
Natural Product Research, 2020, Vol 34, Issue 4, p553
- ISSN
1478-6419
- Publication type
Academic Journal
- DOI
10.1080/14786419.2018.1489387