Title: New hepatoprotective isoflavone glucosides from Pueraria lobata (Willd.) Ohwi.
Authors: Sun, Yingjie; Zhang, Hongmin; Cheng, Ming; Cao, Shijie; Qiao, Miao; Zhang, Boli; Ding, Liqin; Qiu, Feng
Abstract: Two new isoflavone glucosides, 3′-methoxyneopuerarin A (1) and 3′-methoxyneopuerarin B (2), together with nine known isoflavones including puerarin (3), neopuerarin A (4), neopuerarin B (5), daidzin (6), daidzein (7), 3′-methoxypuerarin (PG-3) (8), puerarin xyloside (9), mirificin (10), 3′-hydroxypuerarin (11) were isolated from the water extraction of the dried roots of Pueraria lobata (Willd.) Ohwi. Their structures were elucidated by the means of spectroscopic and chromatographic analysis methods. All compounds were evaluated for their hepatoprotective activity on HepG2 cells. All of them showed statistically significant hepatoprotective effect.
Subjects: GLUCOSIDES; PUERARIA; CHROMATOGRAPHIC analysis; ISOFLAVONES
Publication: Natural Product Research, 2019, Vol 33, Issue 24, p3485
ISSN: 1478-6419
Publication type: Academic Journal
DOI: 10.1080/14786419.2018.1484461

New hepatoprotective isoflavone glucosides from Pueraria lobata (Willd.) Ohwi.

Sun, Yingjie; Zhang, Hongmin; Cheng, Ming; Cao, Shijie; Qiao, Miao; Zhang, Boli; Ding, Liqin; Qiu, Feng