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- Title
New hepatoprotective isoflavone glucosides from Pueraria lobata (Willd.) Ohwi.
- Authors
Sun, Yingjie; Zhang, Hongmin; Cheng, Ming; Cao, Shijie; Qiao, Miao; Zhang, Boli; Ding, Liqin; Qiu, Feng
- Abstract
Two new isoflavone glucosides, 3′-methoxyneopuerarin A (1) and 3′-methoxyneopuerarin B (2), together with nine known isoflavones including puerarin (3), neopuerarin A (4), neopuerarin B (5), daidzin (6), daidzein (7), 3′-methoxypuerarin (PG-3) (8), puerarin xyloside (9), mirificin (10), 3′-hydroxypuerarin (11) were isolated from the water extraction of the dried roots of Pueraria lobata (Willd.) Ohwi. Their structures were elucidated by the means of spectroscopic and chromatographic analysis methods. All compounds were evaluated for their hepatoprotective activity on HepG2 cells. All of them showed statistically significant hepatoprotective effect.
- Subjects
GLUCOSIDES; PUERARIA; CHROMATOGRAPHIC analysis; ISOFLAVONES
- Publication
Natural Product Research, 2019, Vol 33, Issue 24, p3485
- ISSN
1478-6419
- Publication type
Academic Journal
- DOI
10.1080/14786419.2018.1484461