Title: Drug combination studies of curcumin and genistein against rhodesain of Trypanosoma brucei rhodesiense.
Authors: Ettari, Roberta; Previti, Santo; Maiorana, Santina; Allegra, Alessandro; Schirmeister, Tanja; Grasso, Silvana; Zappalà, Maria
Abstract: Curcumin and genistein are two natural products obtained from Curcuma longa L. and soybeans, endowed with many biological properties. Within the last years they were shown to possess also a promising antitrypanosomal activity. In the present paper, we investigated the activity of both curcumin and genistein against rhodesain, the main cysteine protease of Trypanosoma brucei rhodesiense; drug combination studies, according to Chou and Talalay method, allowed us to demonstrate a potent synergistic effect for the combination curcumin-genistein. As a matter of fact, with our experiments we observed that the combination index of curcumin-genistein is < 1 for the reduction from 10 to 90% of rhodesain activity.
Subjects: TRYPANOSOMA brucei; GENISTEIN; TURMERIC; NATURAL products; CURCUMIN
Publication: Natural Product Research, 2019, Vol 33, Issue 24, p3577
ISSN: 1478-6419
Publication type: Academic Journal
DOI: 10.1080/14786419.2018.1483927

Drug combination studies of curcumin and genistein against rhodesain of Trypanosoma brucei rhodesiense.

Ettari, Roberta; Previti, Santo; Maiorana, Santina; Allegra, Alessandro; Schirmeister, Tanja; Grasso, Silvana; Zappalà, Maria