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- Title
Drug combination studies of curcumin and genistein against rhodesain of Trypanosoma brucei rhodesiense.
- Authors
Ettari, Roberta; Previti, Santo; Maiorana, Santina; Allegra, Alessandro; Schirmeister, Tanja; Grasso, Silvana; Zappalà, Maria
- Abstract
Curcumin and genistein are two natural products obtained from Curcuma longa L. and soybeans, endowed with many biological properties. Within the last years they were shown to possess also a promising antitrypanosomal activity. In the present paper, we investigated the activity of both curcumin and genistein against rhodesain, the main cysteine protease of Trypanosoma brucei rhodesiense; drug combination studies, according to Chou and Talalay method, allowed us to demonstrate a potent synergistic effect for the combination curcumin-genistein. As a matter of fact, with our experiments we observed that the combination index of curcumin-genistein is < 1 for the reduction from 10 to 90% of rhodesain activity.
- Subjects
TRYPANOSOMA brucei; GENISTEIN; TURMERIC; NATURAL products; CURCUMIN
- Publication
Natural Product Research, 2019, Vol 33, Issue 24, p3577
- ISSN
1478-6419
- Publication type
Academic Journal
- DOI
10.1080/14786419.2018.1483927