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- Title
Potential anti-inflammation nor-oleanane triterpenoids from the fruits of Stauntonia brachyanthera.
- Authors
Yang, Wei; Chen, Mei; Meng, Dali; Wei, Peifeng
- Abstract
The studies on Stauntonia brachyanthera led to the isolations of 7 normal and nor-oleanane triterpenoids, including 2 new ones. Compounds 1 and 3 showed moderate inhibitory activity on lipopolysaccharide (LPS)-induced nitric oxide production in RAW 264.7 macrophages with the IC50 values of 16.09 and 20.19 μM, respectively, which were stronger than that of positive control. A primary structure-activity relationship was also discussed, which revealed the anti-inflammation abilities of three types triterpenoids and their potential possibilities as the candidate compounds for the treatment of inflammation.
- Subjects
TRITERPENOIDS; FRUIT; STRUCTURE-activity relationships; NITRIC oxide
- Publication
Natural Product Research, 2019, Vol 33, Issue 23, p3350
- ISSN
1478-6419
- Publication type
Academic Journal
- DOI
10.1080/14786419.2018.1475388