Title: Antimicrobial and cytotoxic juglones from the immature exocarps of Juglans mandshurica.
Authors: Yang, Qin; Yao, Qing-Shou; Kuang, Yi; Zhang, Yue-Zhi; Feng, Ling-Ling; Zhang, Lu; Guo, Lin; Xie, Ze-Ping; Zhang, Shu-Min
Abstract: Juglonols A−C (1−3), three new juglone derivatives possessing a hydroxyethyl side chain, were isolated from an organic extract of the immature exocarps of Juglans mandshurica together with five known tetralones (4–8). Their structures were elucidated by extensive spectroscopic analyses and comparison with literature data. The new juglone derivatives exhibited inhibitory activities towards a panel of bacteria and fungi, as well as cancer cell lines. In contrast, the known tetralone homologues (4−8) appeared to be much less efficacy.
Subjects: WALNUT; CELL lines; TETRALONES; CANCER cells
Publication: Natural Product Research, 2019, Vol 33, Issue 22, p3203
ISSN: 1478-6419
Publication type: Academic Journal
DOI: 10.1080/14786419.2018.1468326

Antimicrobial and cytotoxic juglones from the immature exocarps of Juglans mandshurica.

Yang, Qin; Yao, Qing-Shou; Kuang, Yi; Zhang, Yue-Zhi; Feng, Ling-Ling; Zhang, Lu; Guo, Lin; Xie, Ze-Ping; Zhang, Shu-Min