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- Title
Antimicrobial and cytotoxic juglones from the immature exocarps of Juglans mandshurica.
- Authors
Yang, Qin; Yao, Qing-Shou; Kuang, Yi; Zhang, Yue-Zhi; Feng, Ling-Ling; Zhang, Lu; Guo, Lin; Xie, Ze-Ping; Zhang, Shu-Min
- Abstract
Juglonols A−C (1−3), three new juglone derivatives possessing a hydroxyethyl side chain, were isolated from an organic extract of the immature exocarps of Juglans mandshurica together with five known tetralones (4–8). Their structures were elucidated by extensive spectroscopic analyses and comparison with literature data. The new juglone derivatives exhibited inhibitory activities towards a panel of bacteria and fungi, as well as cancer cell lines. In contrast, the known tetralone homologues (4−8) appeared to be much less efficacy.
- Subjects
WALNUT; CELL lines; TETRALONES; CANCER cells
- Publication
Natural Product Research, 2019, Vol 33, Issue 22, p3203
- ISSN
1478-6419
- Publication type
Academic Journal
- DOI
10.1080/14786419.2018.1468326