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- Title
Insecticidal and α-glucosidase inhibitory activities of chemical constituents from Viburnum fordiae Hance.
- Authors
Shao, Jian-Hua; Chen, Jia; Zhao, Chun-Chao; Shen, Jie; Liu, Wen-Yan; Gu, Wen-Yan; Li, Ke-Huan
- Abstract
The ethanolic extract of the stems of Viburnum fordiae Hance showed insecticidal and α-glucosidase inhibitory activities and then was fractionated by bioactivity-guided fractionation to obtain a rare C13-norisoprenoid (1), together with a new phenolic glycoside (2), and seven known compounds, alangionoside C (3), pisumionoside (4), koaburaside (5), 3,5-dimethoxy-benzyl alcohol 4-O-β-d-glucopyranoside (6), 3,4,5-trimethoxybenzyl-β-d-glucopyranoside (7), arbutin (8), and salidroside (9). The previously undescribed compounds were elucidated as (3R,9R)-3-hydroxy-7,8-didehydro-β-ionyl 9-O-α-d-arabinopyranosyl-(1→6)-β-d-glucopyranoside (1) and 2-(4-O-β-d-glucopyranosyl)syringylpropane-1,3-diol (2) by spectroscopic data (1H and 13C NMR, HSQC, HMBC, 1H-1H COSY, HSQC-TOCSY, HRESIMS, IR and ORD) and chemical methods. Compound 1 showed potent insecticidal effect against Mythimna separata with LD50 value of 140 μg g−1. Compounds 2, 5, 6, 8 and 9 showed varying α-glucosidase inhibitory activity with IC50 values ranging from 148.2 to 230.9 μM.
- Subjects
VIBURNUM; GLUCOSIDASES; ACRYLONITRILE; ALCOHOL
- Publication
Natural Product Research, 2019, Vol 33, Issue 18, p2662
- ISSN
1478-6419
- Publication type
Academic Journal
- DOI
10.1080/14786419.2018.1466130