Results
Title

Screening of medicinal plants traditionally used in Peruvian Amazon for in vitro antioxidant and anticancer potential.

Authors

Tauchen, Jan; Huml, Lukas; Bortl, Ludvik; Doskocil, Ivo; Jarosova, Veronika; Marsik, Petr; Frankova, Adela; Clavo Peralta, Zoyla Mirella; Chuspe Zans, Maria-Elena; Havlik, Jaroslav; Lapcik, Oldrich; Kokoska, Ladislav

Abstract

Plants mentioned in this study have numerous records in traditional Peruvian medicine being used in treatment of cancer and other diseases likely to be associated with oxidative stress. Amongst the eight plant species tested, only Dysphania ambrosioides exhibited combinatory antioxidant and anti-proliferative effect on a broad spectrum of cancer cells (DPPH and ORAC values = 80.6 and 687.3 μg TE/mg extract, respectively; IC50 against Caco-2, HT-29 and Hep-G2 = 129.2, 69.9 and 130.6, respectively). Alkaloids and phenolic compounds might significantly contribute to anticancer/antioxidant activity of this plant. The results justify the traditional medicinal use of this plant. Our findings further suggest that D. ambrosioides might serve as a prospective material for further development of novel plant-based antioxidant and/or anti-proliferative agents. Detailed analysis of chemical composition together with toxicology assessments and in vivo antioxidant/anti-proliferative activity of this plant should be carried out in order to verify its potential practical use.

Subjects

AMAZON River Region; MEDICINAL plants; ANALYTICAL chemistry; PHENOLS; OXIDATIVE stress; ANTIOXIDANTS

Publication

Natural Product Research, 2019, Vol 33, Issue 18, p2718

ISSN

1478-6419

Publication type

Academic Journal

DOI

10.1080/14786419.2018.1462180