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- Title
Potential hypoglycemic effect of acetophenones from the root bark of Cynanchum wilfordii.
- Authors
Jiang, Hao-Wen; Gu, Shan-Shan; Cao, Lei; Jiang, Sheng-Shi; Lin, Jing; Chen, Yan; Wang, Ling; Jiao, He; Li, Jing-Ya; Zhao, Wei-Min; Li, Jin-Long
- Abstract
Three new acetophenones, named cynwilforones A–C (1–3), together with cynandione A (4) were isolated from the root bark of Cynanchum wilfordii (Maxim.) Hemsl. Their structures were deduced based on spectroscopic analysis and chemical methods. Compounds 1 and 4 exhibited potential hypoglycemic effects through inhibition of hepatic gluconeogenesis by down-regulating the expression of phosphoenolpyruvate carboxykinase and glucose-6-phosphatase. This is the first report that acetophenones from the root bark of C. wilfordii possesses potential hypoglycemic activity in vitro.
- Subjects
BARK; ACETOPHENONE; ANALYTICAL chemistry; GLUCONEOGENESIS
- Publication
Natural Product Research, 2019, Vol 33, Issue 16, p2314
- ISSN
1478-6419
- Publication type
Academic Journal
- DOI
10.1080/14786419.2018.1443100